Department of Cardiovascular Center, The First Hospital of Jilin University, Changchun, Jilin, China.
Department of ophthalmology, The Second Hospital of Jilin University, Changchun, Jilin, China.
Phytother Res. 2019 May;33(5):1302-1317. doi: 10.1002/ptr.6324. Epub 2019 Mar 4.
It has been extensively verified that inflammation and oxidative stress play important roles in the pathogenesis of cardiovascular diseases (CVDs). Curcuminoids, from the plant Curcuma longa, have three major active ingredients, which include curcumin (curcumin I), demethoxycurcumin, and bisdemethoxycurcumin. Curcuminoids have been used in traditional medicine for CVDs' management and other comorbidities for centuries. Numerous studies had delineated their anti-inflammatory, antioxidative, and other medicinally relevant properties. Animal experiments and clinical trials have also demonstrated that turmeric and curcuminoids can effectively reduce atherosclerosis, cardiac hypertrophy, hypertension, ischemia/reperfusion injury, and diabetic cardiovascular complications. In this review, we introduce and summarize curcuminoids' molecular and biological significance, while focusing on their mechanistic anti-inflammatory/antioxidative involvements in CVDs and preventive effects against CVDs, and, finally, discuss relevant clinical applications.
大量研究证实，炎症和氧化应激在心血管疾病（CVDs）的发病机制中发挥着重要作用。姜黄素有三种主要活性成分，分别是姜黄素（姜黄素 I）、脱甲氧基姜黄素和双脱甲氧基姜黄素。姜黄素有几个世纪以来一直被用于传统医学中治疗 CVDs 及其它合并症。大量研究描述了其抗炎、抗氧化等具有医学相关性的特性。动物实验和临床试验也表明， turmeric 和姜黄素可以有效减少动脉粥样硬化、心脏肥大、高血压、缺血/再灌注损伤和糖尿病心血管并发症。在这篇综述中，我们介绍和总结了姜黄素的分子和生物学意义，重点讨论了其在 CVDs 中的抗炎/抗氧化作用机制及其对 CVDs 的预防作用，并最后讨论了相关的临床应用。
