Cutler J J, Parker G S, Rosen S, Prenney B, Healey R, Caldwell G G
Public Health Rep. 1986 Mar-Apr;101(2):201-5.
Possible associations between environmental hazards and the occurrence of childhood leukemia were investigated in Woburn, MA, for the period 1969-79. Residents of Woburn were concerned over what they perceived to be a large number of childhood leukemia cases; at the same time there was extensive publicity about uncontrolled hazardous waste sites in Woburn, which resulted in its being placed on the Superfund list. Many believed that the elevated rate of childhood leukemia was related to these sites or to two city water wells that had been closed in 1979 when they were found to be contaminated by organic chemicals. An occurrence was defined as childhood leukemia when it was diagnosed in a Woburn resident less than 20 years old between 1969 and 1979 and confirmed by review of hospital and pathology records. This investigation confirmed an increase in incidence which was distributed uniformly over the 11-year period. Six of the persons with leukemia were located close to each other in one census tract, 7.5 times the expected number. Parents of the children and of two matched control groups were interviewed about medical history, mother's pregnancy history, school history, and environmental exposures. There were no significant differences between the leukemia victims and persons in the control groups. No leukemia sufferer had contact with a hazardous waste site. While the contaminants of Wells G and H, which had been closed, are not known leukemogens, it is not possible to rule out exposure to this water as a factor, particularly in the eastern Woburn residents.
1969年至1979年期间，在马萨诸塞州沃本对环境危害与儿童白血病发病之间可能存在的关联进行了调查。沃本居民对他们认为数量众多的儿童白血病病例感到担忧；与此同时，沃本存在不受控制的危险废物场地，这一情况被广泛报道，导致该市被列入超级基金名单。许多人认为儿童白血病发病率升高与这些场地或与两口城市水井有关，这两口井在1979年被发现受到有机化学品污染后被关闭。当1969年至1979年间在沃本居住且年龄小于20岁的居民被诊断为儿童白血病，并经医院和病理记录复查确认时，该病例被定义为儿童白血病发病。这项调查证实发病率有所上升，且在11年期间均匀分布。其中6名白血病患者在一个普查区彼此相邻，是预期数量的7.5倍。对患病儿童的父母以及两个匹配对照组的父母就病史、母亲的妊娠史、上学史和环境暴露情况进行了访谈。白血病患者与对照组人员之间没有显著差异。没有白血病患者接触过危险废物场地。虽然已关闭的G井和H井的污染物并非已知的致白血病物质，但不能排除接触这种水是一个因素，特别是对沃本东部的居民而言。
