Laval G, Souillet G, Philippe N, Tuyns A
Unité de pédiatrie hématologique, Hôpital Debrousse, Lyon, France.
Pediatrie. 1988;43(1):59-65.
To test the large number of hypotheses proposed as causes for childhood leukemia, a case control study was carried out on every child diagnosed for acute leukemia between 1.1.1977 and 12.31.1982, under the age of 15 and living in the region of Lyon (Rhône-Alpes and Saône-et-Loire). Some factors could not be confirmed, possibly in relation with the relatively small sample size (208 cases). Others were confirmed, especially the excess of incidence among 2 to 4 year old children and those belonging to higher socioeconomic groups. Two new factors were identified: the age of the father (over 40 years at child birth) and the profession of the father (manipulation of meat in the few years prior the diagnosis of leukemia in the child).
为了检验作为儿童白血病病因提出的大量假说，对1977年1月1日至1982年12月31日期间在里昂地区（罗纳-阿尔卑斯和索恩-卢瓦尔）确诊的每一名15岁以下急性白血病患儿进行了一项病例对照研究。一些因素无法得到证实，这可能与样本量相对较小（208例）有关。其他因素得到了证实，尤其是2至4岁儿童以及社会经济地位较高群体的发病率过高。还确定了两个新因素：父亲的年龄（孩子出生时超过40岁）和父亲的职业（在孩子白血病诊断前几年从事肉类加工）。
