School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
Mini Rev Med Chem. 2019;19(4):292-309. doi: 10.2174/1389557518666181026091449.
As noteworthy members of the terpenoid family, iridoids are a group of natural compounds that have a cyclopentane ring and hemiacetal structural features. Among them, phenylpropionyl iridoids- widely present in Bignoniaceae, Rubiaceae, Scrophulariaceae, Verbenaceae, and Oleaceae- were discovered and extracted from plants mainly between the 1980s and 2000s. Because of their unique structural features and complex stereo configurations, these compounds exhibit numerous desirable biological activities such as neuroprotective, anti-inflammatory, antimicrobial, and antitumour activities; they have received increasing interest recently. This review summarises progress in research on phenylpropionyl iridoids, including their occurrence and biological activities.
作为萜类家族的重要成员，环烯醚萜是一类具有环戊烷环和半缩醛结构特征的天然化合物。其中，苯丙酰基环烯醚萜广泛存在于木樨科、茜草科、玄参科、马鞭草科和橄榄科，主要从 20 世纪 80 年代到 2000 年代从植物中被发现和提取出来。由于其独特的结构特征和复杂的立体构型，这些化合物表现出许多理想的生物活性，如神经保护、抗炎、抗菌和抗肿瘤活性；最近它们受到了越来越多的关注。本文综述了苯丙酰基环烯醚萜的研究进展，包括其存在和生物活性。
