Institute of Clinical Medical Sciences, Department of Pharmacy, China-Japan Friendship Hospital, Beijing, China.
School of Life Sciences, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
Med Res Rev. 2023 Jul;43(4):1201-1252. doi: 10.1002/med.21949. Epub 2023 Mar 10.
Secoiridoids are natural products of cyclopentane monoterpene derivatives that are formed by splitting the rings of cyclomethene oxime compounds at C-7 and C-8, and only account for a small part of cyclic ether terpenoids. Because of the chemically active hemiacetal structure in their common basic skeleton, secoiridoids have a wide range of biological activities, such as neuroprotective, anti-inflammatory, antidiabetic, hepatoprotective, and antinociceptive activities. Phenolic secoiridoids can also act against multiple molecular targets involved in human tumorigenesis, making them potentially valuable precursors for antitumor drug development. This review provides a detailed update, covering relevant discoveries from January 2011 to December 2020, about the occurrence, structural diversity, bioactivities, and synthesis of naturally occurring secoiridoids. We aimed to resolve the lack of extensive, specific, and thorough review of secoiridoids, as well as open new areas for pharmacological investigation and better drugs based on these compounds.
环烯醚萜类化合物是由环戊烷单萜衍生物形成的天然产物，通过在 C-7 和 C-8 处裂解环烯肟化合物的环，仅占环醚萜类化合物的一小部分。由于其共同基本骨架中具有化学活性的半缩醛结构，环烯醚萜类化合物具有广泛的生物活性，如神经保护、抗炎、抗糖尿病、保肝和抗伤害感受活性。酚类环烯醚萜类化合物还可以针对涉及人类肿瘤发生的多个分子靶标发挥作用，使它们成为抗肿瘤药物开发的潜在有价值的前体。本综述提供了详细的更新，涵盖了 2011 年 1 月至 2020 年 12 月期间关于天然存在的环烯醚萜类化合物的发生、结构多样性、生物活性和合成的相关发现。我们旨在解决缺乏对环烯醚萜类化合物的广泛、具体和彻底的综述问题，并为基于这些化合物的药理学研究和更好的药物开辟新的领域。
