Trenchard D
Respir Physiol. 1986 Feb;63(2):227-40. doi: 10.1016/0034-5687(86)90116-7.
The CO2/H+ sensitivity of 'pulmonary' non-myelinated vagal afferent endings was investigated in anaesthetized rabbits using 'natural' stimuli of lactic (LA) and acetic (AA) acids, for comparison with previous results using sodium dithionite (NaD) and phenyl biguanide (PDG). Right atrial injections of these four chemicals demonstrated a respiratory reflex from 'pulmonary' endings, consisting primarily of a decrease in expiratory duration and consequent increase in respiratory frequency coincident with transient increase in PETCO2. Three of the chemicals (AA, LA and NaD) apparently activated the endings by increased [CO2] and/or [H+], since equimolar doses of sodium lactate and acetate were without effect. PDG additionally elicited respiratory and cardiovascular reflexes from 'cardiac' endings, suggesting that its activation of 'pulmonary' endings may differ from the other three stimuli. An unforeseen complication of these studies arose from using SPF (specific pathogen free) rabbits, but the consistency of different control values in SPF rabbits was established.
在麻醉兔中，使用乳酸（LA）和乙酸（AA）作为“天然”刺激物，研究了“肺”非髓鞘迷走神经传入末梢对二氧化碳/氢离子的敏感性，并与之前使用连二亚硫酸钠（NaD）和苯双胍（PDG）的结果进行比较。右心房注射这四种化学物质显示出源于“肺”末梢的呼吸反射，主要表现为呼气持续时间缩短，随后呼吸频率增加，同时呼气末二氧化碳分压（PETCO2）短暂升高。其中三种化学物质（AA、LA和NaD）显然是通过增加二氧化碳浓度和/或氢离子浓度来激活末梢的，因为等摩尔剂量的乳酸钠和醋酸钠没有效果。PDG还引发了源于“心脏”末梢的呼吸和心血管反射，这表明它对“肺”末梢的激活可能与其他三种刺激不同。这些研究出现了一个意外的并发症，即使用无特定病原体（SPF）兔，但确定了SPF兔中不同对照值的一致性。
