School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, People's Republic of China.
Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou, People's Republic of China.
Nat Prod Res. 2020 Aug;34(15):2194-2201. doi: 10.1080/14786419.2019.1582038. Epub 2019 Mar 5.
A new cadinane-type sesquiterpenoid, microporotriol (), together with four known compound, 5-methylresorcinol (), (22,24)-ergosta-4,6,8(14),22-tetraen-3-one (), (22,24)-ergosta-5,7,22-trien-3-ol (), (22,24)-5,8-epidioxy-ergosta-6,22-dien-3-ol (), were isolated from the fermentation broth of the wood decaying fungus HFG829. The structures of the compounds were established by extensive spectroscopic methods, including 1D & 2D NMR, along with HRMS spectroscopic analysis. The relative configuration of was confirmed by NMR calculation. Compound was evaluated for the cytotoxicity against five human cancer cell lines.
一种新的卡丹烷型倍半萜，微孔三醇（），以及四种已知化合物，5-甲基间苯二酚（），（22,24）-麦角甾-4,6,8(14),22-四烯-3-酮（），（22,24）-麦角甾-5,7,22-三烯-3-醇（），（22,24）-5,8-表二氧代-麦角甾-6,22-二烯-3-醇（），从腐朽木材真菌 HFG829 的发酵液中分离得到。通过广泛的光谱方法，包括 1D 和 2D NMR 以及高分辨率质谱光谱分析，确定了化合物的结构。通过 NMR 计算确定了的相对构型。对化合物进行了对五种人癌细胞系的细胞毒性评价。
