Nanjing University of Traditional Chinese Medicine, Nanjing, China.
Nat Prod Res. 2020 Aug;34(15):2243-2247. doi: 10.1080/14786419.2019.1582048. Epub 2019 Mar 5.
In the present study, five new -kaurane diterpenes including 4α-hydroxy-17,19---kaurane-16-one (), 4-hydroxy-16-H-18---kaurane-17-oic acid (), 4,17-dihydroxy-16α-acetoxy-18-nor--kaurane (), Annosquamosin Z () and 16-H--kaurane-17,18-dioic acid, 17-methy ester () were isolated from L. pericarp. The compounds were also evaluated for their cytotoxic activities against SMMC-7721 and HepG2 cell lines, among which compound exhibited potent cytotoxicity with IC value of less than 20 μM.
在本研究中，从 L. 果皮中分离得到了五个新的贝壳杉烷二萜类化合物，包括 4α-羟基-17,19---贝壳杉烷-16-酮 ()、4-羟基-16-H-18---贝壳杉烷-17-酸 ()、4,17-二羟基-16α-乙酰氧基-18-去甲--贝壳杉烷 ()、 Annosquamosin Z () 和 16-H--贝壳杉烷-17,18-二酸，17-甲酯 ()。还评估了这些化合物对 SMMC-7721 和 HepG2 细胞系的细胞毒性活性，其中化合物 表现出很强的细胞毒性，IC 值小于 20 μM。
