a The Peter Harrison Centre for Disability Sport; School of Sport, Exercise, and Health Sciences , Loughborough University , Loughborough , UK.
b Department of Rehabilitation Medicine , Wakayama Medical University , Wakayama , Japan.
J Sports Sci. 2019 Aug;37(15):1717-1724. doi: 10.1080/02640414.2019.1586296. Epub 2019 Mar 5.
This study investigates the relationship between autonomic function and the inflammatory response to a wheelchair half-marathon in people with a spinal cord injury (SCI). Seventeen wheelchair athletes with a cervical SCI (CSCI, N = 7) and without CSCI (NON-CSCI, N = 10) participated in a wheelchair half-marathon. Blood was taken prior, post and 1 h post-race to determine the concentrations of adrenaline, noradrenaline, extracellular heat shock protein 72 (eHsp72) and interleukin-6 (IL-6). A sit-up tilt test was performed to assess autonomic function at rest. CSCI showed a lower supine ratio of the low and high frequency power of the variability in RR intervals (LF/HF RRI, = 0.038), total and low frequency power of the systolic blood pressure variability (TP SBP, < 0.001; LF SBP, = 0.005) compared to NON-CSCI. Following the race, catecholamine concentrations increased only in NON-CSCI ( < 0.036). The increase in IL-6 post-race was larger in NON-CSCI ( = 0.040). Post-race catecholamine levels explained 60% of the variance in the IL-6 response ( = 0.77, = 0.040), which was further increased when the resting autonomic function indices were added to the regression model (R > 81%, < 0.012). In summary, the dampened acute inflammatory response to a wheelchair half-marathon in CSCI was strongly associated with the autonomic dysfunction present in this group.
本研究调查了自主功能与脊髓损伤（SCI）患者参加轮椅半程马拉松比赛时炎症反应之间的关系。17 名颈髓损伤（CSCI）轮椅运动员（CSCI 组，N = 7）和无 CSCI（NON-CSCI 组，N = 10）参加了轮椅半程马拉松比赛。比赛前后和赛后 1 小时采集血液，以确定肾上腺素、去甲肾上腺素、细胞外热休克蛋白 72（eHsp72）和白细胞介素 6（IL-6）的浓度。还进行了仰卧倾斜试验，以评估自主功能在休息时的情况。CSCI 组的 RR 间期低频和高频功率比（LF/HF RRI， = 0.038）、收缩压变异性的总功率和低频功率（TP SBP， < 0.001；LF SBP， = 0.005）均低于 NON-CSCI 组。比赛后，NON-CSCI 组儿茶酚胺浓度仅升高（ < 0.036）。NON-CSCI 组赛后的 IL-6 增加幅度更大（ = 0.040）。赛后儿茶酚胺水平解释了 IL-6 反应的 60%的变异（ = 0.77， = 0.040），当将静息自主功能指标添加到回归模型时，这一比例进一步增加（R > 81%， < 0.012）。总之，CSCI 患者在参加轮椅半程马拉松比赛时，急性炎症反应减弱与该组存在的自主功能障碍密切相关。
