Scherzer Nickolas D, Le Tan V, Hellstrom Wayne J G
Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA.
Department of Andrology, Binh Dan Hospital, Ho Chi Minh City, Vietnam.
Int J Impot Res. 2019 Mar;31(2):71-73. doi: 10.1038/s41443-018-0067-x. Epub 2019 Mar 5.
Sildenafil has had a dramatic influence on the field of sexual medicine over the past 20 years. Not only have phosphodiesterase-5 (PDE5) inhibitors improved the treatment of erectile dysfunction (ED), they have indirectly contributed to the treatment of male factor infertility. A review of the literature between 1998 - 2018 was performed using PubMed with regards to sildenafil and male infertility. Numerous studies have demonstrated sildenafil's safety and efficacy for treating ED. Sildenafil does not alter semen parameters, and, in fact, may positively affect semen parameters. Sildenafil is helpful for treating ED caused by the psychological stress of infertility treatments. Sildenafil has improved the treatment of ED and may have a benefit on semen parameters. This has aided in the management of male factor infertility, and has contributed to hundreds of thousands of pregnancies that would have been more difficult, as it was before its advent.
在过去20年里，西地那非对性医学领域产生了巨大影响。磷酸二酯酶-5（PDE5）抑制剂不仅改善了勃起功能障碍（ED）的治疗，还间接推动了男性因素不孕症的治疗。使用PubMed对1998年至2018年间关于西地那非和男性不育的文献进行了综述。大量研究已证明西地那非治疗ED的安全性和有效性。西地那非不会改变精液参数，事实上，它可能对精液参数产生积极影响。西地那非有助于治疗由不育治疗的心理压力引起的ED。西地那非改善了ED的治疗，并且可能对精液参数有益。这有助于男性因素不孕症的管理，并促成了数十万例妊娠，要是在它问世之前，这些妊娠会困难得多。
