钾稳态与高钾血症的病理生理学
Potassium homoeostasis and pathophysiology of hyperkalaemia.
作者信息
Kjeldsen Keld Per, Schmidt Thomas Andersen
机构信息
Department of Medicine, Copenhagen University Hospital (Holbæk Hospital), Smedelundsgade 60, DK Holbæk, Denmark.
Institute of Clinical Medicine, Copenhagen University, Blegdamsvej 3B, Copenhagen, Denmark.
出版信息
Eur Heart J Suppl. 2019 Feb;21(Suppl A):A2-A5. doi: 10.1093/eurheartj/suy033. Epub 2019 Feb 26.
Abstract
Determination of potassium level is one of the most frequent laboratory tests in clinical medicine. Hyperkalaemia is defined as a potassium level >5.0 mmol/L and is one of the most clinically important electrolyte abnormalities, because it may cause dangerous cardiac arrhythmia and sudden cardiac death. Here, we review methodological challenges in the determination of potassium levels, important clinical aspects of the potassium homoeostasis as well as of the pathophysiology of hyperkalaemia.
摘要
血钾水平测定是临床医学中最常见的实验室检查之一。高钾血症定义为血钾水平>5.0 mmol/L，是临床上最重要的电解质异常之一，因为它可能导致危险的心律失常和心源性猝死。在此，我们综述血钾水平测定中的方法学挑战、钾稳态的重要临床方面以及高钾血症的病理生理学。
相似文献
1
Potassium homoeostasis and pathophysiology of hyperkalaemia.钾稳态与高钾血症的病理生理学
Eur Heart J Suppl. 2019 Feb;21(Suppl A):A2-A5. doi: 10.1093/eurheartj/suy033. Epub 2019 Feb 26.
2
Potassium binders for chronic hyperkalaemia in people with chronic kidney disease.用于慢性肾脏病患者慢性高钾血症的钾结合剂。
Cochrane Database Syst Rev. 2020 Jun 26;6(6):CD013165. doi: 10.1002/14651858.CD013165.pub2.
3
Evaluation of the effect of sodium zirconium cyclosilicate on arrhythmia-related cardiovascular outcomes in patients receiving chronic haemodialysis with hyperkalaemia: protocol for the multicentre, randomised, controlled DIALIZE-Outcomes study.评价环硅酸锆钠对高钾血症接受慢性血液透析患者心律失常相关心血管结局的影响：多中心、随机、对照 DIALIZE-Outcomes 研究方案。
BMJ Open. 2023 May 25;13(5):e071309. doi: 10.1136/bmjopen-2022-071309.
4
Pharmacological interventions for the acute management of hyperkalaemia in adults.成人高钾血症急性处理的药物干预措施。
Cochrane Database Syst Rev. 2015 Oct 29;10(10):CD010344. doi: 10.1002/14651858.CD010344.pub2.
5
Effect of prophylactic treatment with low-molecular-weight heparin bemiparin sodium on serum potassium levels: a prospective observational study.预防性使用低分子肝素贝米肝素钠对血清钾水平的影响：一项前瞻性观察研究。
Drugs Aging. 2010 May;27(5):399-406. doi: 10.2165/11535440-000000000-00000.
6
Hyperkalaemia prevalence and dialysis patterns in Chinese patients on haemodialysis: an interim analysis of a prospective cohort study (PRECEDE-K).血液透析患者高钾血症的患病率和透析模式：一项前瞻性队列研究（PRECEDE-K）的中期分析。
BMC Nephrol. 2023 Aug 9;24(1):233. doi: 10.1186/s12882-023-03261-8.
7
Prevalence and factors associated with false hyperkalaemia in Asians in primary care: a cross-sectional study (the Unlysed Hyperkalaemia- the Unseen Burden (UHUB) study).在初级保健中，亚洲人群中假性高钾血症的流行情况及相关因素：一项横断面研究（未分析的高钾血症-未被重视的负担（UHUB）研究）。
BMJ Open. 2020 Sep 22;10(9):e033755. doi: 10.1136/bmjopen-2019-033755.
8
Long-term mortality and trajectory of potassium measurements following an episode of acute severe hyperkalaemia.急性重度高钾血症发作后钾测量的长期死亡率和轨迹。
Nephrol Dial Transplant. 2022 Feb 25;37(3):522-530. doi: 10.1093/ndt/gfab003.
9
Interventions for non-oliguric hyperkalaemia in preterm neonates.早产儿非少尿性高钾血症的干预措施。
Cochrane Database Syst Rev. 2012 May 16;2012(5):CD005257. doi: 10.1002/14651858.CD005257.pub3.
10
A method comparison study of a point-of-care blood gas analyser with a laboratory auto-analyser for the determination of potassium concentrations during hyperkalaemia in patients with kidney disease.床边血气分析仪与实验室自动分析仪测定肾病高钾血症患者血钾浓度的方法比较研究。
Biochem Med (Zagreb). 2020 Oct 15;30(3):030702. doi: 10.11613/BM.2020.030702. Epub 2020 Aug 5.
引用本文的文献
1
Effect of A1470T Polymorphism on Lactate and Potassium Concentrations After Caffeine Ingestion During Acute Resistance Exercise.A1470T多态性对急性抗阻运动期间摄入咖啡因后乳酸和钾浓度的影响。
Nutrients. 2024 Dec 21;16(24):4396. doi: 10.3390/nu16244396.
2
Epidemiology and risk factors for hyperkalaemia in heart failure.心力衰竭患者高钾血症的流行病学和危险因素。
ESC Heart Fail. 2024 Aug;11(4):1821-1840. doi: 10.1002/ehf2.14661. Epub 2024 Mar 4.
3
The Effect of Starting Blood Glucose Levels on Serum Electrolyte Concentrations during and after Exercise in Type 1 Diabetes.1 型糖尿病患者运动期间和运动后起始血糖水平对血清电解质浓度的影响。
Int J Environ Res Public Health. 2023 Jan 24;20(3):2109. doi: 10.3390/ijerph20032109.
本文引用的文献
1
Protection against severe hypokalemia but impaired cardiac repolarization after intense rowing exercise in healthy humans receiving salbutamol.沙丁胺醇治疗健康人剧烈划船运动后严重低钾血症，但损害心脏复极。
J Appl Physiol (1985). 2018 Aug 1;125(2):624-633. doi: 10.1152/japplphysiol.00680.2017. Epub 2018 May 10.
2
Expert consensus document on the management of hyperkalaemia in patients with cardiovascular disease treated with renin angiotensin aldosterone system inhibitors: coordinated by the Working Group on Cardiovascular Pharmacotherapy of the European Society of Cardiology.专家共识文件：血管紧张素转换酶抑制剂或血管紧张素受体拮抗剂治疗的心血管疾病患者的高钾血症管理：由欧洲心脏病学会心血管药理学工作组协调。
Eur Heart J Cardiovasc Pharmacother. 2018 Jul 1;4(3):180-188. doi: 10.1093/ehjcvp/pvy015.
3
Potassium and the use of renin-angiotensin-aldosterone system inhibitors in heart failure with reduced ejection fraction: data from BIOSTAT-CHF.心力衰竭射血分数降低患者中钾离子与肾素-血管紧张素-醛固酮系统抑制剂的应用：BIOSTAT-CHF 研究数据。
Eur J Heart Fail. 2018 May;20(5):923-930. doi: 10.1002/ejhf.1079. Epub 2018 Jan 12.
4
Potassium Homeostasis in Health and Disease: A Scientific Workshop Cosponsored by the National Kidney Foundation and the American Society of Hypertension.健康与疾病中的钾稳态：由国家肾脏基金会和美国高血压学会联合主办的科学研讨会。
Am J Kidney Dis. 2017 Dec;70(6):844-858. doi: 10.1053/j.ajkd.2017.09.003. Epub 2017 Oct 10.
5
Mineralocorticoid receptor antagonists in patients with heart failure: current experience and future perspectives.醛固酮受体拮抗剂在心力衰竭患者中的应用：当前经验与未来展望。
Eur Heart J Cardiovasc Pharmacother. 2017 Jan;3(1):48-57. doi: 10.1093/ehjcvp/pvw016. Epub 2016 Aug 2.
6
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC.2016欧洲心脏病学会急性和慢性心力衰竭诊断与治疗指南：欧洲心脏病学会（ESC）急性和慢性心力衰竭诊断与治疗特别工作组。由ESC心力衰竭协会（HFA）特别贡献制定。
Eur J Heart Fail. 2016 Aug;18(8):891-975. doi: 10.1002/ejhf.592. Epub 2016 May 20.
7
A new era for the treatment of hyperkalemia?高钾血症治疗的新时代？
N Engl J Med. 2015 Jan 15;372(3):275-7. doi: 10.1056/NEJMe1414112. Epub 2014 Nov 21.
8
Do hemolyzed potassium specimens need to be repeated?溶血的钾标本需要重新检测吗？
J Emerg Med. 2014 Sep;47(3):313-7. doi: 10.1016/j.jemermed.2014.04.019. Epub 2014 Jun 13.
9
ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD).与欧洲糖尿病研究协会（EASD）合作制定的欧洲心脏病学会（ESC）糖尿病、糖尿病前期和心血管疾病指南：欧洲心脏病学会（ESC）糖尿病、糖尿病前期和心血管疾病特别工作组与欧洲糖尿病研究协会（EASD）合作制定。
Eur Heart J. 2013 Oct;34(39):3035-87. doi: 10.1093/eurheartj/eht108. Epub 2013 Aug 30.
10
2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC).2013年欧洲高血压学会（ESH）和欧洲心脏病学会（ESC）动脉高血压管理指南：欧洲高血压学会（ESH）和欧洲心脏病学会（ESC）动脉高血压管理特别工作组
Eur Heart J. 2013 Jul;34(28):2159-219. doi: 10.1093/eurheartj/eht151. Epub 2013 Jun 14.
Zotero 插件