Rahimi Mohammad Rahman, Faraji Hassan, Hajipoor Seyyed Rasoul, Ahmetov Ildus I
Department of Exercise Physiology, University of Kurdistan, Sanandaj 66177-15175, Iran.
Department of Physical Education and Sports Science, Marivan Branch, Islamic Azad University, Marivan 14778-93855, Iran.
Nutrients. 2024 Dec 21;16(24):4396. doi: 10.3390/nu16244396.
The monocarboxylate transporter 1 (MCT1) plays a crucial role in regulating lactate and pyruvate transport across cell membranes, which is essential for energy metabolism during exercise. The A1470T (rs1049434) polymorphism has been suggested to influence lactate transport, with the T (major) allele associated with greater transport efficiency. This study aimed to investigate the effect of the polymorphism on lactate and potassium (K) concentrations in response to resistance exercise (RE) following caffeine (CAF) ingestion.
Thirty resistance-trained athletes were randomly selected to participate in a randomized, double-blind, placebo-controlled crossover study. Participants consumed either CAF (6 mg/kg of body weight) or a placebo (PL; 6 mg of maltodextrin per kg of body weight) one hour before performing RE. Serum lactate and potassium concentrations were measured before exercise (Pre), immediately after (Post), and 15 min post-exercise (15 min Post). The RE protocol consisted of three sets to failure at 85% of 1RM for each exercise, with 2 min rest intervals between sets.
The findings indicate that under caffeine consumption, individuals carrying the A (minor) allele had significantly higher blood lactate levels before ( = 0.037) and immediately after ( = 0.0001) resistance exercise compared to those with the TT genotype. Additionally, caffeine consumption moderated the increase in plasma potassium levels in TT genotype carriers, while A allele carriers exhibited elevated potassium levels 15 min post-exercise, regardless of caffeine or placebo intake ( < 0.05).
Our findings suggest that the A1470T polymorphism may influence lactate metabolism and clearance under caffeine consumption, potentially impacting exercise performance and recovery.
单羧酸转运蛋白1（MCT1）在调节乳酸和丙酮酸跨细胞膜转运中起关键作用，这对运动期间的能量代谢至关重要。已表明A1470T（rs1049434）多态性会影响乳酸转运，其中T（主要）等位基因与更高的转运效率相关。本研究旨在调查该多态性对摄入咖啡因（CAF）后进行抗阻运动（RE）时乳酸和钾（K）浓度的影响。
随机选取30名经过抗阻训练的运动员参与一项随机、双盲、安慰剂对照的交叉研究。参与者在进行抗阻运动前1小时摄入CAF（6毫克/千克体重）或安慰剂（PL；每千克体重6毫克麦芽糊精）。在运动前（Pre）、运动后即刻（Post）和运动后15分钟（15分钟Post）测量血清乳酸和钾浓度。抗阻运动方案包括每项运动以1RM的85%进行三组至力竭，组间休息2分钟。
研究结果表明，在摄入咖啡因的情况下，与TT基因型个体相比，携带A（次要）等位基因的个体在抗阻运动前（P = 0.037）和运动后即刻（P = 0.0001）的血乳酸水平显著更高。此外，摄入咖啡因可缓解TT基因型携带者血浆钾水平的升高，而无论摄入咖啡因还是安慰剂，A等位基因携带者在运动后15分钟时钾水平均升高（P < 0.05）。
我们的研究结果表明，A1470T多态性可能会影响摄入咖啡因时的乳酸代谢和清除，潜在影响运动表现和恢复。
