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[Paraneoplastic chorea and behavioral disorders in a patient with anti-CV2/CRMP5 antibodies and two different tumors].[一名抗CV2/CRMP5抗体阳性且患有两种不同肿瘤的患者出现副肿瘤性舞蹈症和行为障碍]
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Secondary parkinsonism associated with focal brain lesions.与局灶性脑病变相关的继发性帕金森综合征。
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Elevated Hippocampal CRMP5 Mediates Chronic Stress-Induced Cognitive Deficits by Disrupting Synaptic Plasticity, Hindering AMPAR Trafficking, and Triggering Cytokine Release.海马体中 CRMP5 水平升高通过破坏突触可塑性、阻碍 AMPAR 运输以及引发细胞因子释放，介导慢性应激引起的认知缺陷。
Int J Mol Sci. 2023 Mar 3;24(5):4898. doi: 10.3390/ijms24054898.
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Parkinsonism and dysautonomia with anti-CV2/CRMP5 associated paraneoplastic neurological syndromes mimicking multiple system atrophy: a case report.帕金森病和自主神经功能障碍伴抗 CV2/CRMP5 相关副肿瘤性神经综合征，类似多系统萎缩：病例报告。
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Antibody-Negative Paraneoplastic Limbic Encephalitis, Parkinsonism, Hypothermia, and Narcolepsy Associated with Endometrial Carcinoma.与子宫内膜癌相关的抗体阴性副肿瘤性边缘叶脑炎、帕金森综合征、体温过低和发作性睡病
Mov Disord Clin Pract. 2020 Jan 7;7(2):223-227. doi: 10.1002/mdc3.12883. eCollection 2020 Feb.
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Neuropathology and pathogenesis of extrapyramidal movement disorders: a critical update-I. Hypokinetic-rigid movement disorders.锥体外系运动障碍的神经病理学和发病机制：批判性更新-I. 运动减少-僵硬的运动障碍。
J Neural Transm (Vienna). 2019 Aug;126(8):933-995. doi: 10.1007/s00702-019-02028-6. Epub 2019 Jun 18.
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Movement disorders with neuronal antibodies: syndromic approach, genetic parallels and pathophysiology.神经元抗体相关运动障碍：综合征方法、遗传相似性和病理生理学。
Brain. 2018 Jan 1;141(1):13-36. doi: 10.1093/brain/awx189.

本文引用的文献

1
Severe parkinsonism associated with anti-CRMP5 antibody-positive paraneoplastic neurological syndrome and abnormal signal intensity in the bilateral basal ganglia.与抗CRMP5抗体阳性副肿瘤性神经综合征及双侧基底节异常信号强度相关的严重帕金森症
J Neurol Neurosurg Psychiatry. 2016 Aug;87(8):907-10. doi: 10.1136/jnnp-2015-311569. Epub 2015 Sep 15.
2
Analysis of C9orf72 repeat expansions in a large series of clinically and pathologically diagnosed cases with atypical parkinsonism.对大量临床和病理诊断的非典型帕金森病病例中C9orf72重复扩增的分析。
Neurobiol Aging. 2015 Feb;36(2):1221.e1-6. doi: 10.1016/j.neurobiolaging.2014.08.024. Epub 2014 Aug 27.
3
Paraneoplastic neurological syndromes.副肿瘤性神经系统综合征
Clin Exp Immunol. 2014 Mar;175(3):336-48. doi: 10.1111/cei.12185.
4
PET/CT in diagnosis of movement disorders.PET/CT 在运动障碍诊断中的应用。
Ann N Y Acad Sci. 2011 Jun;1228:93-108. doi: 10.1111/j.1749-6632.2011.06025.x.
5
Movement disorders caused by medical disease.由内科疾病引起的运动障碍。
Semin Neurol. 2009 Apr;29(2):97-110. doi: 10.1055/s-0029-1213731. Epub 2009 Apr 15.
6
Role of FDG-PET in the clinical management of paraneoplastic neurological syndrome: detection of the underlying malignancy and the brain PET-MRI correlates.氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）在副肿瘤性神经系统综合征临床管理中的作用：潜在恶性肿瘤的检测及脑部PET-MRI相关性
Mol Imaging Biol. 2008 May-Jun;10(3):131-7. doi: 10.1007/s11307-008-0134-7. Epub 2008 Feb 23.
7
Localization of CRMP5 mRNA by in situ hybridisation during development of the mouse forebrain.在小鼠前脑发育过程中通过原位杂交对CRMP5 mRNA进行定位。
Neurosci Lett. 2008 Feb 20;432(2):117-20. doi: 10.1016/j.neulet.2007.12.011. Epub 2007 Dec 15.
8
Recommended diagnostic criteria for paraneoplastic neurological syndromes.副肿瘤性神经系统综合征的推荐诊断标准。
J Neurol Neurosurg Psychiatry. 2004 Aug;75(8):1135-40. doi: 10.1136/jnnp.2003.034447.
9
CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity.CRMP-5神经元自身抗体：肺癌和胸腺瘤相关自身免疫的标志物。
Ann Neurol. 2001 Feb;49(2):146-54.

Paraneoplastic Atypical Parkinsonism with Anti-CRMP5 Antibodies and Severe Caudate and Putaminal Hypometabolism on 18-Fluorodeoxyglucose Positron Emission Tomography of the Brain.

作者信息

Yap Siew Mei, Lynch Tim, MacMahon Peter, Murray Brian

机构信息

Department of Neurology Mater Misericordiae University Hospital Dublin Ireland.

Department of Radiology Mater Misericordiae University Hospital Dublin Ireland.

出版信息

Mov Disord Clin Pract. 2016 Jun 6;4(2):263-265. doi: 10.1002/mdc3.12370. eCollection 2017 Mar-Apr.

DOI:10.1002/mdc3.12370
PMID:30838264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6353453/
Abstract
摘要