Müller P, Dammann H G, Simon B
Arzneimittelforschung. 1986 Feb;36(2):265-8.
The deleterious effects of acetylsalicylic acid (ASA) on gastric mucosa have been well documented in experimental and clinical studies. With a direct endoscopic assay system we evaluated in healthy volunteers whether pretreatment with prostaglandin analogues (misoprostol, rioprostil), omeprazole and ranitidine prevented ASA-induced gastric mucosal injuries. Ranitidine (2 X 150 mg/d) in large antisecretory doses almost completely abolished these changes (p less than 0.05). By contrast, misoprostol (4 X 50 micrograms/d and 4 X 200 micrograms/d), rioprostil (3 X 100 micrograms/d), omeprazole (5 mg and 10 mg/d) as well as ranitidine in non-antisecretory doses (2 X 25 mg/d) did not reduce gastric mucosal injury after single-dose ASA administration. The results of this trial indicate that socalled cytoprotective doses of prostaglandins, omeprazole and ranitidine in contrast to animal findings are not effective in preventing acute ASA-induced mucosal damage.
乙酰水杨酸（ASA）对胃黏膜的有害作用在实验和临床研究中已有充分记录。我们使用直接内镜检测系统，在健康志愿者中评估前列腺素类似物（米索前列醇、利奥前列素）、奥美拉唑和雷尼替丁预处理是否能预防ASA诱导的胃黏膜损伤。大剂量抑酸的雷尼替丁（2×150mg/d）几乎完全消除了这些变化（p<0.05）。相比之下，米索前列醇（4×50μg/d和4×200μg/d）、利奥前列素（3×100μg/d）、奥美拉唑（5mg和10mg/d）以及非抑酸剂量的雷尼替丁（2×25mg/d）在单剂量ASA给药后并未减轻胃黏膜损伤。该试验结果表明，与动物研究结果相反，所谓的前列腺素、奥美拉唑和雷尼替丁的细胞保护剂量在预防急性ASA诱导的黏膜损伤方面无效。
