神经元特异性烯醇化酶在抽动障碍中的作用新见解。
New insights into the role of neuron-specific enolase in tic disorders.
机构信息
Shanghai Jiao Tong University School of Medicine, 227 Chongqing Road, Shanghai, 200025, People's Republic of China.
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, People's Republic of China.
出版信息
Neurol Sci. 2019 Jun;40(6):1167-1172. doi: 10.1007/s10072-019-03811-9. Epub 2019 Mar 5.
OBJECTIVE
Neuron-specific enolase (NSE) has been suggested for demonstrating brain metabolism in neuropsychiatric disorders. This study assessed serum NSE levels in patients with tic disorders (TD).
METHODS
In this retrospective case-control study, we investigated whether NSE levels were increased in TD patients. Then, the influencing factors and correlations between NSE levels and clinical features were analyzed. Finally, we tested its diagnostic value for identifying tic severity.
RESULTS
NSE levels were increased in TD patients, although no statistically significant difference was present between transient TD, chronic TD, and Tourette syndrome. Factors influencing NSE levels assessed by multiple linear regression were the Yale Global Tic Severity Scale (YGTSS) global severity scores and gender. There were significant correlations between NSE levels and tic severity. The optimal cut-off value to distinguish mild tics from moderate-severe tics estimated by receiver operating characteristics curve was 24.95 ng/ml (AUC = 0.683).
CONCLUSION
Our findings suggested that NSE may be a significant biomarker in TD but should be confirmed in further investigation.
目的
神经元特异性烯醇化酶（NSE）已被建议用于显示神经精神疾病中的脑代谢。本研究评估了抽动障碍（TD）患者的血清 NSE 水平。
方法
在这项回顾性病例对照研究中，我们研究了 NSE 水平是否在 TD 患者中升高。然后，分析了 NSE 水平与临床特征之间的影响因素和相关性。最后，我们测试了其识别抽动严重程度的诊断价值。
结果
TD 患者的 NSE 水平升高，尽管短暂性 TD、慢性 TD 和妥瑞氏综合征之间没有统计学上的显著差异。多元线性回归评估的影响 NSE 水平的因素是耶鲁总体抽动严重程度量表（YGTSS）总体严重程度评分和性别。NSE 水平与抽动严重程度之间存在显著相关性。通过受试者工作特征曲线估计区分轻度抽动和中重度抽动的最佳截断值为 24.95ng/ml（AUC=0.683）。
结论
我们的研究结果表明，NSE 可能是 TD 的一个重要生物标志物，但需要进一步研究证实。
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