Silvestri Paola R, Chiarotti Flavia, Baglioni Valentina, Neri Valeria, Cardona Francesco, Cavanna Andrea E
Department of Pediatrics and Child Neuropsychiatry, Sapienza University, Rome, Italy.
Department of Cell Biology and Neuroscience, National Institute of Health, Rome, Italy.
Neurol Sci. 2016 Nov;37(11):1857-1860. doi: 10.1007/s10072-016-2682-y. Epub 2016 Jul 25.
Gilles de la Tourette syndrome (GTS) is a neurodevelopmental condition characterised by tics and co-morbid behavioural problems, affecting predominantly male patients. Tic severity typically fluctuates over time, with a consistent pattern showing improvement after adolescence in a considerable proportion of patients. Both tics and behavioural co-morbidities have been shown to have the potential to affect patients' health-related quality of life (HR-QoL) in children and adults with persisting symptoms. In this study, we present the results of the first investigation of HR-QoL in patients with Gilles de la Tourette syndrome at the transition between adolescence and adulthood using a disease-specific HR-QoL measure, the Gilles de la Tourette Syndrome-Quality of Life-Children and Adolescents scale. Our results showed that patients with GTS and more severe co-morbid anxiety symptoms reported lower HR-QoL across all domains, highlighting the impact of anxiety on patient's well-being at a critical stage of development. Routine screening for anxiety symptoms is recommended in all patients with GTS seen at transition clinics from paediatric to adult care, to implement effective behavioural and pharmacological interventions as appropriate.
抽动秽语综合征（GTS）是一种神经发育障碍，其特征为抽动及共病行为问题，主要影响男性患者。抽动严重程度通常随时间波动，相当一部分患者呈现出青春期后症状改善的一致模式。抽动及行为共病均已显示出可能会影响有持续症状的儿童和成人患者与健康相关的生活质量（HR-QoL）。在本研究中，我们使用特定疾病的HR-QoL测量工具——抽动秽语综合征儿童及青少年生活质量量表，首次呈现了处于青春期和成年期过渡阶段的抽动秽语综合征患者HR-QoL的调查结果。我们的结果表明，患有GTS且共病焦虑症状更严重的患者在所有领域的HR-QoL得分较低，这凸显了焦虑在发育关键阶段对患者幸福感的影响。建议在从儿科到成人护理的过渡诊所就诊的所有GTS患者中常规筛查焦虑症状，以便酌情实施有效的行为和药物干预。
