Tamaki K, Furue M, Seki Y, Inoue Y, Tsuchida T, Ohara K, Kukita A
Br J Dermatol. 1986 Apr;114(4):451-8. doi: 10.1111/j.1365-2133.1986.tb02849.x.
Lectin-binding sites in sections of formalin-fixed, paraffin-embedded eccrine sweat gland tumours were investigated using fluorescein isothiocyanate (FITC) conjugated peanut agglutinin (PNA), FITC conjugated Ricinus communis 1 agglutinin (RCA-1) and FITC conjugated wheat germ agglutinin (WGA). In 22 benign eccrine sweat gland tumours, lectin-binding sites were noted primarily on the cell surface, and in the secretions. In five malignant sweat gland tumours, all showed cytoplasmic lectin-binding sites in variable proportions of malignant cells in addition to cell surface staining. These results indicate that cytoplasmic lectin-binding sites may be a useful marker of neoplastic transformation of eccrine sweat gland tumours.
利用异硫氰酸荧光素（FITC）偶联的花生凝集素（PNA）、FITC偶联的蓖麻凝集素1（RCA-1）和FITC偶联的麦胚凝集素（WGA），对福尔马林固定、石蜡包埋的小汗腺肿瘤切片中的凝集素结合位点进行了研究。在22例良性小汗腺肿瘤中，凝集素结合位点主要见于细胞表面和分泌物中。在5例恶性汗腺肿瘤中，除细胞表面染色外，所有肿瘤在不同比例的恶性细胞中均显示出细胞质凝集素结合位点。这些结果表明，细胞质凝集素结合位点可能是小汗腺肿瘤发生肿瘤转化的一个有用标志物。
