Division of Infection, Immunity & Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Manchester Adult Cystic Fibrosis Centre, Wythenshawe Hospital, Manchester Foundation NHS Trust, Manchester, UK.
Pediatr Pulmonol. 2019 Jun;54(6):770-777. doi: 10.1002/ppul.24290. Epub 2019 Mar 5.
Inflammatory arthritis in the context of cystic fibrosis (CF) can represent a diagnostic and therapeutic challenge. Poor recognition and under-treatment of musculoskeletal conditions increases symptom burden, affects quality of life, and may lead to changes to an individual's ability to carry out activities of daily living and to exercise. A careful assessment and multidisciplinary approach is essential when considering a diagnosis of CF-associated arthritis (CFA), both in terms of identifying other treatable conditions, such as rheumatoid arthritis, and effectively addressing symptoms. In this collaboration between CF specialists and Rheumatologists, we consider joint symptoms in patients with CF, with a focus on CFA. We offer a differential diagnosis list and consider steps to assess and manage CF patients presenting with arthralgia including appropriate up-to-date rheumatological assessment.
在囊性纤维化 (CF) 的背景下，炎症性关节炎可能是一个诊断和治疗的挑战。对肌肉骨骼疾病认识不足和治疗不足会增加症状负担，影响生活质量，并可能导致个体进行日常生活活动和锻炼的能力发生变化。在考虑 CF 相关关节炎 (CFA) 的诊断时，无论是识别其他可治疗的疾病，如类风湿关节炎，还是有效地解决症状，都需要进行仔细的评估和多学科方法。在 CF 专家和风湿病学家的合作下，我们考虑了 CF 患者的关节症状，重点是 CFA。我们提供了鉴别诊断列表，并考虑了评估和管理出现关节痛的 CF 患者的步骤，包括进行最新的风湿病学评估。
