Rush P J, Shore A, Coblentz C, Wilmot D, Corey M, Levison H
Semin Arthritis Rheum. 1986 Feb;15(3):213-25. doi: 10.1016/0049-0172(86)90018-1.
Twenty-seven patients with CF and joint complaints were reviewed. Twelve patients had arthritis, 11 had HPO, and four had symptoms of mechanical neck and back pain. We have confirmed the association of CF with an episodic form of arthritis. For the first time, we have reported that a subgroup of these patients later develop persistent synovitis with progressive asymmetric, erosive disease. The etiology of CF arthritis is unclear, but may relate to chronic infection and immune complex mechanisms. CF arthritis can be contrasted with CF induced HPO, which is associated with worse lung disease, a male predominance, and an older mean age of onset of symptoms. Mechanical neck and back pain may relate to an associated scoliosis or kyphosis in CF.
对27例患有囊性纤维化（CF）并伴有关节问题的患者进行了回顾性研究。12例患者患有关节炎，11例患有肥大性骨关节病（HPO），4例有机械性颈背痛症状。我们证实了CF与一种发作性关节炎形式之间的关联。我们首次报告，这些患者中的一个亚组后来会发展为持续性滑膜炎，并伴有进行性不对称性侵蚀性疾病。CF关节炎的病因尚不清楚，但可能与慢性感染和免疫复合物机制有关。CF关节炎可与CF诱发的HPO形成对比，后者与更严重的肺部疾病、男性居多以及症状出现的平均年龄较大有关。机械性颈背痛可能与CF相关的脊柱侧弯或后凸有关。
