Clarke Elizabeth, Taylor Julia, Watson Pippa, Freeston Jane, Jones Andrew, Peckham Daniel, Horsley Alex
Division of Infection, Immunity & Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Rheumatology Department, Royal Alexandra Hospital, NHS Greater Glasgow and Clyde.
Pediatr Pulmonol. 2025 Jan;60(1):e27418. doi: 10.1002/ppul.27418. Epub 2024 Dec 2.
Musculoskeletal problems are reported in the literature as a common problem for people with cystic fibrosis, with a range of aetiologies including an inflammatory arthritis. However, accurate data on the presentations and prevalence are lacking. The aim of this cohort study was to describe the scale and impact of musculoskeletal symptoms in CF.
A collaboratively designed questionnaire was administered to adults attending two large UK CF centres. Data collected evaluated scale and impact of musculoskeletal symptoms.
Results were obtained from 489 patients (response rate 59%). Of these, 49% reported that musculoskeletal symptoms impacted their activities of daily living in the previous year. Back pain was common, occurring in 44% of participants in the preceding week. The knee was the most commonly affected painful peripheral joint, with 26% of participants reporting knee pain within the last week rising to 50% within the last year. Early morning stiffness and joint swelling were markedly less common, suggesting that the majority of musculoskeletal pain in CF is not due to an inflammatory arthritis but is due to other factors.
Musculoskeletal problems are common in CF and frequently affect activities of daily living. Symptoms of inflammatory arthritis occurred in only a small minority of individuals. A focused approach to characterising and clarifying the aetiology of musculoskeletal symptoms is needed to inform the management of these disabling symptoms.
文献报道肌肉骨骼问题是囊性纤维化患者的常见问题，其病因多样，包括炎性关节炎。然而，关于其表现和患病率的准确数据尚缺。这项队列研究的目的是描述囊性纤维化患者肌肉骨骼症状的规模及影响。
向在英国两个大型囊性纤维化中心就诊的成年人发放一份联合设计的问卷。收集的数据评估了肌肉骨骼症状的规模及影响。
共获得489名患者的结果（应答率59%）。其中，49%的患者报告称肌肉骨骼症状在过去一年影响了他们的日常生活活动。背痛很常见，在前一周有44%的参与者出现背痛。膝盖是最常受影响的疼痛外周关节，26%的参与者报告上周膝盖疼痛，而去年这一比例升至50%。晨僵和关节肿胀明显较少见，这表明囊性纤维化患者的大多数肌肉骨骼疼痛并非由炎性关节炎引起，而是由其他因素导致。
肌肉骨骼问题在囊性纤维化患者中很常见，且经常影响日常生活活动。炎性关节炎症状仅在少数个体中出现。需要采取针对性方法来确定和阐明肌肉骨骼症状的病因，以便为这些致残症状的管理提供依据。
