Brundin P, Isacson O, Gage F H, Prochiantz A, Björklund A
Brain Res. 1986 Feb 26;366(1-2):346-9. doi: 10.1016/0006-8993(86)91316-8.
Mice were first administered intrastriatal injections of 6-hydroxydopamine and subsequently a sub-group was given neural cell suspension grafts prepared from 14-day-old fetal ventral mesencephalic mouse tissue. Six and 8 weeks after transplantation the mice in the grafted group exhibited a significant reduction in amphetamine-induced turning behaviour towards the lesioned side compared to non-grafted lesioned controls. Six of the 7 mice that had surviving grafts containing histofluorescent dopamine neurons eventually showed a reversed motor side bias with more amphetamine-induced turning in a direction away from the transplant.
首先给小鼠进行纹状体内注射6-羟基多巴胺，随后将一组小鼠给予由14日龄胎鼠腹侧中脑小鼠组织制备的神经细胞悬浮移植物。移植后6周和8周时，与未移植的损伤对照组相比，移植组小鼠由苯丙胺诱导的向损伤侧旋转行为显著减少。在7只移植物中含有组织荧光多巴胺神经元的存活小鼠中，有6只最终表现出运动侧偏性反转，更多的苯丙胺诱导的旋转方向远离移植物。
