Koulu M, Saavedra J M, Niwa M, Linnoila M
Brain Res. 1986 Mar 26;369(1-2):361-4. doi: 10.1016/0006-8993(86)90551-2.
Young, 4-week-old spontaneously hypertensive rats (SHR) had significantly higher concentrations of dopamine and 3,4-dihydroxyphenylacetic acid and a faster rate of accumulation of L-dihydroxyphenylalanine after decarboxylase inhibition in the locus coeruleus than age-matched Wistar-Kyoto rats, whereas the norepinephrine levels were similar to each other. In the brainstem, these changes were restricted to the locus coeruleus and were not present in adult, 14-week-old rats with established hypertension. These results are suggestive of a noradrenergic overactivity in the locus coeruleus of young SHR, coinciding with the development of the hypertension.
4周龄的年轻自发性高血压大鼠（SHR），其蓝斑中多巴胺和3,4-二羟基苯乙酸的浓度显著高于年龄匹配的Wistar-Kyoto大鼠，并且在脱羧酶抑制后L-二羟基苯丙氨酸的积累速度更快，而去甲肾上腺素水平彼此相似。在脑干中，这些变化仅限于蓝斑，在14周龄患有高血压的成年大鼠中不存在。这些结果表明，年轻SHR的蓝斑中去甲肾上腺素能过度活跃，这与高血压的发展相一致。
