Felten S Y, Weyhenmeyer J A, Felten D L
Brain Res Bull. 1984 Sep;13(3):437-41. doi: 10.1016/0361-9230(84)90095-9.
Neurochemical analysis of norepinephrine and serotonin with high performance liquid chromatography with electrochemical detection (LCEC) in several microdissected central autonomic nuclei of 4 week old and 16 week old spontaneously hypertensive rats (SHR), normotensive Wistar-Kyoto rats (WKY), and control normotensive Wistar rats (WIS), revealed some differences among these strains, but only one change that correlated with the hypertensive state. Norepinephrine levels in the 4 week old SHR were greater in the parabrachial nuclei and the dorsal motor nucleus of X than in the WKY, but levels in the WIS normotensive also were greater than in the WKY, and equalled levels in the SHR. In the 16 week old rats, no difference was noted between NE levels in the SHR and WKY strains, but levels in the locus coeruleus and parabrachial nuclei of the WIS were greater than in both the SHR and WKY. Serotonin levels in the 4 week old SHR and WKY rats did not differ, while levels in the paraventricular nucleus, locus coeruleus, parabrachial nuclei, and medullary raphe nuclei of the WIS rat were greater than one or both of these inbred strains. In the dorsal motor nucleus of X in 16 week old rats, serotonin levels were greater in the SHR than in either the WKY or WIS controls, suggesting one possible transmitter action that should be explored further for its potential relationship to the hypertensive state.(ABSTRACT TRUNCATED AT 250 WORDS)
采用高效液相色谱电化学检测法（LCEC）对4周龄和16周龄的自发性高血压大鼠（SHR）、血压正常的Wistar - Kyoto大鼠（WKY）以及对照血压正常的Wistar大鼠（WIS）的几个显微切割的中枢自主神经核中的去甲肾上腺素和5-羟色胺进行神经化学分析，结果显示这些品系之间存在一些差异，但只有一个变化与高血压状态相关。4周龄SHR的臂旁核和迷走神经背运动核中的去甲肾上腺素水平高于WKY，但WIS正常血压大鼠的该水平也高于WKY，且与SHR的水平相当。在16周龄大鼠中，SHR和WKY品系的去甲肾上腺素水平没有差异，但WIS的蓝斑核和臂旁核中的水平高于SHR和WKY两者。4周龄SHR和WKY大鼠的5-羟色胺水平没有差异，而WIS大鼠的室旁核、蓝斑核、臂旁核和延髓中缝核的水平高于这两个近交系中的一个或两者。在16周龄大鼠的迷走神经背运动核中，SHR的5-羟色胺水平高于WKY或WIS对照，这表明一种可能的递质作用，应进一步探讨其与高血压状态的潜在关系。（摘要截短至250字）
