Koulu M, Saavedra J M, Niwa M, Scheinin M, Linnoila M
Brain Res. 1986 Apr 16;371(1):177-81. doi: 10.1016/0006-8993(86)90825-5.
Spontaneously hypertensive rats have increased brain stem serotonin turnover localized to the nuclei raphe magnus, raphe pallidus, tractus solitarius and reticularis lateralis. It occurs only in young animals coinciding with the development of hypertension. In the locus coeruleus, increased serotonin metabolism is present during both the early and the established phase of hypertension. Our results provide evidence for serotonergic overactivity in specific brainstem nuclei during the development of spontaneous hypertension in the rat.
自发性高血压大鼠脑干中缝大核、中缝苍白核、孤束核和外侧网状核的血清素周转率增加。这种情况仅发生在与高血压发展同时期的幼龄动物中。在蓝斑核中，血清素代谢增加出现在高血压的早期和已确立阶段。我们的结果为大鼠自发性高血压发展过程中特定脑干核团中血清素能活性过高提供了证据。
