Urner F, Schorderet-Slatkine S
C R Acad Sci III. 1986;302(6):185-90.
Methyltransferase inhibitors such as 5'-methyl-5'-thioadenosine (MTA), 5'-deoxy-5'-isobutylthioadenosine (SIBA) and 5'-deoxy-5'-isobutylthio-3-deaza-adenosine (3-deaza-SIBA) maintain the meiotic prophase block in denuded mouse oocytes. The inhibitory effect is dose-dependent and reversible. This inhibition is potentiated by forskolin and by the phorbol 12,13 dibutyrate (PD Bu), a tumor-promoting phorbol ester.
甲基转移酶抑制剂，如5'-甲基-5'-硫代腺苷（MTA）、5'-脱氧-5'-异丁硫代腺苷（SIBA）和5'-脱氧-5'-异丁硫代-3-脱氮腺苷（3-脱氮-SIBA），可维持去透明带小鼠卵母细胞减数分裂前期阻滞。这种抑制作用具有剂量依赖性且可逆。福斯高林和佛波醇12,13-二丁酸酯（PD Bu，一种促肿瘤佛波酯）可增强这种抑制作用。
