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用硝呋替莫治疗的慢性恰加斯病患者中抗克鲁斯锥虫免疫球蛋白G的定量及长期随访评估

Quantification of Immunoglobulin G against Trypanosoma cruzi in Individuals with Chronic Chagas Disease Treated with Nifurtimox and Evaluated in Prolonged Follow-Up.

作者信息

Muñoz Gabriela, Vergara Camilo, Martínez Gabriela, Apt Werner, Zulantay Inés

机构信息

Laboratory of Basic-Clinical Parasitology, Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.

出版信息

Korean J Parasitol. 2019 Feb;57(1):39-41. doi: 10.3347/kjp.2019.57.1.39. Epub 2019 Feb 26.

DOI:10.3347/kjp.2019.57.1.39
PMID:30840798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6409214/
Abstract

In the indeterminate chronic period of Chagas disease (ChD) the treatment has not been conclusive, because the serological negativization requires many years. This study aims to evaluate the efficacy of nifurtimox (NF) in the treatment of chronic ChD in prolonged follow-up by serological techniques of indirect immunofluorescence assay (IFA) and enzyme-linked immunosorbent assay (ELISA) IgG comparing 2 groups of patients, treated and non treated. Mann-Whitney test was performed for ELISA and IFA, with significant difference between the groups (P < 0.05). IgG levels were lower in individuals treated compared with untreated patients, indicating chemotherapeutic efficacy in prolonged follow-up.

摘要

在恰加斯病（ChD）的不确定慢性期，治疗尚无定论，因为血清学转阴需要很多年。本研究旨在通过间接免疫荧光测定法（IFA）和酶联免疫吸附测定法（ELISA）IgG的血清学技术，比较两组接受治疗和未接受治疗的患者，评估硝呋莫司（NF）在长期随访中治疗慢性ChD的疗效。对ELISA和IFA进行了曼-惠特尼检验，两组之间存在显著差异（P<0.05）。与未治疗患者相比，接受治疗的个体IgG水平较低，表明在长期随访中具有化疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c5e/6409214/42edb7f8eebc/kjp-57-1-39f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c5e/6409214/8cf653806993/kjp-57-1-39f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c5e/6409214/42edb7f8eebc/kjp-57-1-39f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c5e/6409214/8cf653806993/kjp-57-1-39f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c5e/6409214/42edb7f8eebc/kjp-57-1-39f2.jpg

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本文引用的文献

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Chagas disease.恰加斯病。
Lancet. 2018 Jan 6;391(10115):82-94. doi: 10.1016/S0140-6736(17)31612-4. Epub 2017 Jun 30.
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Course of Chronic Trypanosoma cruzi Infection after Treatment Based on Parasitological and Serological Tests: A Systematic Review of Follow-Up Studies.基于寄生虫学和血清学检测的治疗后慢性克氏锥虫感染病程：随访研究的系统评价
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[Comparison of conventional and non-conventional serological tests for the diagnosis of imported Chagas disease in Spain].[西班牙用于诊断输入性恰加斯病的传统和非传统血清学检测方法比较]
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