Braun D P, Harris J E
Cancer Immunol Immunother. 1986;21(3):240-5. doi: 10.1007/BF00199368.
The effects of cytotoxic chemotherapy on NK cell function and on glass adherent cell regulation of NK cell function was evaluated in the peripheral blood mononuclear cells of 20 previously untreated solid tumor patients. Most of the patients studied had lung cancer and received one of four combination chemotherapy treatment regimens. In addition, one patient with colon carcinoma and one patient with melanoma were studied, each of whom received treatment with a single agent. The results demonstrated that chemotherapy exerted a differential influence on NK activity which correlated with the pretreatment NK level of function in the individual patient. In patients with depressed NK levels prior to treatment, chemotherapy augmented NK function; in patients with normal levels prior to treatment, chemotherapy depressed NK function. The effects observed appeared to be associated with the capacity of chemotherapy to influence glass adherent cell regulation of NK activity. There was no apparent correlation between the effects of chemotherapy on numbers of NK effector cells, Leu11+ cells, or latex-ingesting cells. Also, there was no correlation between the effects seen and the type of drug treatment that was administered; rather, this was dependent on the pretreatment NK level of function which in turn was associated with glass adherent cell regulation of NK function.
在20例未经治疗的实体瘤患者的外周血单核细胞中，评估了细胞毒性化疗对自然杀伤（NK）细胞功能以及对NK细胞功能的玻璃黏附细胞调节作用的影响。大多数研究对象为肺癌患者，接受了四种联合化疗方案中的一种。此外，还研究了1例结肠癌患者和1例黑色素瘤患者，他们均接受了单一药物治疗。结果表明，化疗对NK活性有不同影响，这与个体患者治疗前的NK功能水平相关。治疗前NK水平降低的患者，化疗增强了NK功能；治疗前水平正常的患者，化疗则抑制了NK功能。观察到的这些效应似乎与化疗影响NK活性的玻璃黏附细胞调节能力有关。化疗对NK效应细胞数量、Leu11 +细胞数量或吞噬乳胶细胞数量的影响之间没有明显相关性。而且，观察到的效应与所给予的药物治疗类型之间也没有相关性；相反，这取决于治疗前的NK功能水平，而这又与NK功能的玻璃黏附细胞调节有关。
