推进趋化因子 GPCR 结构为基础的药物发现。

Advancing Chemokine GPCR Structure Based Drug Discovery.

机构信息

iHuman Institute, ShanghaiTech University, Shanghai 201210, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.

CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China.

出版信息

Structure. 2019 Mar 5;27(3):405-408. doi: 10.1016/j.str.2019.02.004.

DOI:10.1016/j.str.2019.02.004

PMID:30840872

Abstract

In this issue of Structure, Apel et al., (2019) provide structural insight into the inhibition of a human chemokine G-protein-coupled receptor by a small-molecule antagonist, which advances our understanding of drug design principles for this complex family of receptors.

摘要

在本期《结构》杂志中，Apel 等人（2019 年）提供了人类趋化因子 G 蛋白偶联受体被小分子拮抗剂抑制的结构见解，这推进了我们对这一复杂受体家族药物设计原则的理解。