Ekholm S E, Dahlbäck O, Tylén U
Eur J Radiol. 1986 Feb;6(1):9-11.
Five patients with clinically inoperable bronchial squamous cell carcinoma were treated with infusions of 10 mg Mitomycin-C in the bronchial artery feeding the tumour, in an attempt to make inoperable bronchogenic carcinoma resectable. One patient had only one treatment while the other four had the infusion repeated three times with an interval of two weeks between treatments. In all cases there was a marked regression of the tumour. Four patients had the tumour resected 1-2 weeks following the last treatment and two of these are still alive 2 1/2 and 4 years later. The other two patients died 14 and 22 months following the initiation of the treatment. The fifth patient developed serious adverse effects to the drug that only slowly subsided. He died 5 1/2 months following the initiation of the treatment and his tumour was not resected. This limited study demonstrates the possibility of making certain inoperable patients with bronchogenic carcinoma operable, but it also stresses the problems of a correct preoperative staging.
对5例临床上无法手术切除的支气管鳞状细胞癌患者，通过向供应肿瘤的支气管动脉内输注10毫克丝裂霉素C进行治疗，试图使无法手术切除的支气管源性癌变为可切除。1例患者仅接受了1次治疗，其他4例患者每隔2周重复输注3次。所有病例中肿瘤均有明显消退。4例患者在最后一次治疗后1 - 2周接受了肿瘤切除术，其中2例在2年半和4年后仍然存活。另外2例患者在治疗开始后14个月和22个月死亡。第5例患者出现严重的药物不良反应，且消退缓慢。他在治疗开始后5个半月死亡，其肿瘤未被切除。这项有限的研究证明了使某些无法手术的支气管源性癌患者变为可手术的可能性，但也强调了正确进行术前分期的问题。
