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利奈唑胺与特地唑胺在耐万古霉素肠球菌（VRE）菌血症实验小鼠模型中的疗效比较

Comparative Efficacies of Linezolid vs. Tedizolid in an Experimental Murine Model of Vancomycin-Resistant Enterococcal (VRE) Bacteremia.

作者信息

Abdelhady Wessam, Mishra Nagendra N

机构信息

Division of Infectious Diseases, Los Angeles Biomedical Research Institute at UCLA Medical Center, Torrance, CA, United States.

David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.

出版信息

Front Med (Lausanne). 2019 Feb 20;6:31. doi: 10.3389/fmed.2019.00031. eCollection 2019.

DOI:10.3389/fmed.2019.00031
PMID:30842947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6391330/
Abstract

Tedizolid () is an oxazolidinone derivative which demonstrates bacteriostatic activity through inhibition of protein synthesis. We compared the efficacies of TZD and an earlier-generation oxazolidinone, linezolid (), in an experimental murine model of bacteremia caused by two VRE strains (one each and ). LZD exhibited significantly better efficacy in terms of reduced VRE blood and target tissue densities than TZD in this model.

摘要

替加环素（）是一种恶唑烷酮衍生物，通过抑制蛋白质合成发挥抑菌活性。我们在由两种耐万古霉素肠球菌菌株（各一种）引起的实验性小鼠菌血症模型中比较了替加环素（TZD）和早期一代恶唑烷酮利奈唑胺（）的疗效。在该模型中，就降低耐万古霉素肠球菌血液和靶组织密度而言，利奈唑胺（LZD）的疗效明显优于替加环素（TZD）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18d/6391330/aee66ec2a3ef/fmed-06-00031-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18d/6391330/aee66ec2a3ef/fmed-06-00031-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a18d/6391330/aee66ec2a3ef/fmed-06-00031-g0001.jpg

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FEMS Microbiol Lett. 2018 Feb 1;365(3). doi: 10.1093/femsle/fnx284.
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