Key Laboratory of Macromolecular Science of Shaanxi Province, Key Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, and School of Chemistry & Chemical Engineering , Shaanxi Normal University , Xi'an 710119 , China.
ACS Appl Mater Interfaces. 2019 Mar 27;11(12):11227-11237. doi: 10.1021/acsami.9b01655. Epub 2019 Mar 19.
Recently, luminogens with the aggregation-induced emission characteristic (AIEgens) have received much attention in the field of bioimaging and therapeutic applications. However, the development of AIEgens that are derived from the simple core skeleton with emission color tuning for imaging and therapy is still a formidable challenge. To address this constraint, we present a series of cationic AIEgens based on cyanopyridinium salts (CP1-CP5). The AIEgens can be facilely prepared by varying the aromatic electron donor while fixing the cyanopyridinium group as the electron acceptor within a single benzene ring. The obtained AIEgens possess wide color tunability, large Stokes shifts, and bright emission in the condensed state. Due to their good biocompatibility and cationic nature, these AIEgens can be utilized for multiple-color imaging of intracellular mitochondria as well as Gram-negative and Gram-positive bacteria. Importantly, these AIEgens exhibit remarkable structure-dependent singlet-oxygen generation ability under white light illumination (25 mW cm), and CP4 was optimized to serve as an excellent photosensitizer for photodynamic anticancer and antibacterial therapy.
近年来，具有聚集诱导发光特性（AIEgens）的发光体在生物成像和治疗应用领域受到了广泛关注。然而，开发源自简单核心骨架、具有发射颜色调谐功能的 AIEgens 仍然是一个巨大的挑战。为了解决这个限制，我们提出了一系列基于氰基吡啶盐（CP1-CP5）的阳离子 AIEgens。AIEgens 可以通过改变芳香族供电子体而轻松制备，同时将氰基吡啶基团固定在单苯环内作为电子受体。所得 AIEgens 在凝聚态下具有宽的颜色可调性、大的斯托克斯位移和明亮的发射。由于其良好的生物相容性和阳离子性质，这些 AIEgens 可用于细胞内线粒体以及革兰氏阴性和革兰氏阳性细菌的多色成像。重要的是，这些 AIEgens 在白光照射下（25 mW cm）表现出显著的结构依赖性单线态氧生成能力，并且 CP4 被优化为用于光动力抗癌和抗菌治疗的优秀光敏剂。
