1 Mental Health and Wellbeing Research Group, Department of Public Health, Vrije Universiteit Brussel, Jette, Belgium.
2 Coma Science Group, Cyclotron Research Centre and Neurology Department, University Hospital of Liège, University of Liège, Liège, Belgium.
Palliat Med. 2019 Jun;33(6):712-716. doi: 10.1177/0269216319835149. Epub 2019 Mar 7.
Awareness and pain during palliative sedation is typically assessed by observational scales, but the use of such scales has been put into question.
A woman in her mid-80s was admitted to a palliative care unit, presenting with chronic lymphatic leukemia, depression, and a cerebrovascular accident, with right-sided hemiplegia and aphasia. The patient was unable to eat and was suffering from nausea and vomiting. Before admission, the patient had expressed her desire to discontinue treatment on several occasions.
The decision was made to initiate palliative sedation. The patient consented to take part in a study to assess level of comfort and pain using two monitoring devices (NeuroSense monitor and Analgesia Nociception Index monitor).
The patient died 90 h after initiation of palliative sedation. Titration of the medication was challenging and sedation was not deep enough during the first 2 days. Thirteen assessments made with the Ramsay Sedation Scale showed that the patient was considered to be in a deep sleep, while in fact the NeuroSense monitor indicated otherwise.
This case demonstrates the feasibility and potential advantages of using monitoring devices to objectify assessments of pain and discomfort in palliatively sedated patients.
在姑息性镇静期间,意识和疼痛通常通过观察量表来评估,但这些量表的使用受到了质疑。
一位 80 多岁的女性因慢性淋巴细胞白血病、抑郁症和脑卒中等疾病被收入姑息治疗病房,右侧偏瘫和失语。患者无法进食,伴有恶心和呕吐。入院前,患者曾多次表示希望停止治疗。
决定开始姑息性镇静。患者同意参与一项研究,使用两种监测设备(NeuroSense 监测仪和镇痛感觉指数监测仪)评估舒适度和疼痛程度。
患者在开始姑息性镇静后 90 小时死亡。药物滴定具有挑战性,在前 2 天镇静深度不够。13 次使用 Ramsay 镇静评分进行评估显示,患者被认为处于深度睡眠状态,而实际上 NeuroSense 监测仪显示并非如此。
本病例证明了使用监测设备客观评估姑息性镇静患者疼痛和不适的可行性和潜在优势。