Qiu Yue, Tu Guo-Wei, Ju Min-Jie, Yang Cheng, Luo Zhe
Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Department of Urology, Zhongshan Hospital; Shanghai Key Laboratory of Organ Transplantation, Fudan University, Shanghai 200032, China.
Curr Protein Pept Sci. 2019;20(8):799-816. doi: 10.2174/1389203720666190305164128.
Sepsis, which is a highly heterogeneous syndrome, can result in death as a consequence of a systemic inflammatory response syndrome. The activation and regulation of the immune system play a key role in the initiation, development and prognosis of sepsis. Due to the different periods of sepsis when the objects investigated were incorporated, clinical trials often exhibit negative or even contrary results. Thus, in this review we aim to sort out the current knowledge in how immune cells play a role during sepsis.
脓毒症是一种高度异质性的综合征，可因全身炎症反应综合征而导致死亡。免疫系统的激活和调节在脓毒症的发生、发展及预后中起关键作用。由于纳入研究对象时脓毒症所处阶段不同，临床试验常常呈现出阴性甚至相反的结果。因此，在本综述中，我们旨在梳理目前关于免疫细胞在脓毒症过程中如何发挥作用的知识。
