Chemical Engineering and Process Development Division, CSIR-National Chemical Laboratory, Pune, 4110 008, India.
Org Biomol Chem. 2019 Mar 20;17(12):3239-3248. doi: 10.1039/c9ob00127a.
An efficient method for metal-free C-C bond formation between p-quinone methides (p-QMs) and cyclic ethers via a radical pathway to afford substituted diarylmethanes and triarylmethanes or to effect the α-alkylation of the cyclic ethers has been developed. Also, the synthesis of 3,3'-disubstituted oxindoles with stereogenic quaternary carbon centers was successfully achieved under mild reaction conditions.
一种通过自由基途径在 p-醌甲醚（p-QMs）和环状醚之间形成无金属 C-C 键的有效方法已被开发出来，该方法可用于合成取代的二芳基甲烷和三芳基甲烷，或实现环状醚的α-烷基化。此外，在温和的反应条件下，成功合成了具有手性季碳中心的 3,3'-二取代氧化吲哚。
