Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, KTP Building, 8 College Road, Singapore 169857, Singapore; Centre for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore.
Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, KTP Building, 8 College Road, Singapore 169857, Singapore; Centre for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore.
Curr Opin Virol. 2019 Jun;36:1-8. doi: 10.1016/j.coviro.2019.02.002. Epub 2019 Mar 4.
Dengue virus (DENV) consists of four serotypes. Sequential serotype infections can cause increased disease severity, likely due to antibody-dependent enhancement (ADE) of infection. Here, we review two recent papers showing major advancements in the understanding of the ADE mechanism for both mature and immature DENV. The surface of both mature and immature DENV contains E and another protein - M in mature and prM in immature virus. On mature DENV, the orientation of anti-E antibody with respect to the virus surface determines the antibody enhancement properties. On the immature virus, binding of anti-prM antibody aids the dissociation of pr from the fusion loop of E protein allowing virus-endosomal membrane interaction, thus overcoming the hurdle in the early step of fusion.
登革热病毒（DENV）由四个血清型组成。连续的血清型感染可能导致疾病严重程度增加，这可能是由于抗体依赖性增强（ADE）感染所致。在这里，我们回顾了两篇最近的论文，它们显示了对成熟和不成熟 DENV 的 ADE 机制的理解的重大进展。成熟和不成熟 DENV 的表面都包含 E 蛋白和另一种蛋白 - 在成熟病毒中为 M，在不成熟病毒中为 prM。在成熟 DENV 上，针对 E 蛋白的抗体相对于病毒表面的方向决定了抗体增强特性。在不成熟病毒上，针对 prM 抗体的结合有助于 pr 从 E 蛋白的融合环解离，从而允许病毒-内体膜相互作用，从而克服融合早期步骤中的障碍。
