揭示 2010-2015 年期间来自食品动物（牛、猪和家禽）和肉类（牛和猪）的肠杆菌科中产 ESBL 的 mcr-1 阳性大肠杆菌菌株。
Revealing mcr-1-positive ESBL-producing Escherichia coli strains among Enterobacteriaceae from food-producing animals (bovine, swine and poultry) and meat (bovine and swine), Portugal, 2010-2015.
机构信息
INIAV - National Institute of Agrarian and Veterinary Research, Bacteriology and Micology Laboratory, Oeiras, Portugal.
National Reference Laboratory of Antibiotic Resistances and Healthcare Associated Infections, Department of Infectious Diseases, National Institute of Health Dr Ricardo Jorge, Lisbon, Portugal; Centre for the Studies of Animal Science, Institute of Agrarian and Agri-Food Sciences and Technologies, University of Oporto, Oporto, Portugal.
出版信息
Int J Food Microbiol. 2019 May 2;296:37-42. doi: 10.1016/j.ijfoodmicro.2019.02.006. Epub 2019 Feb 10.
We screened 1840 Enterobacteriaceae isolates from food-producing animals, meat, meat products and animal feed, for the detection of plasmid-mediated colistin resistance, during 2010-2015. The mcr-1 gene was detected in 8.0% (97/1206) Escherichia coli and in 0.47% (3/634) Salmonella enterica isolates, with a high number of mcr-1 positive E. coli isolates (45.7%) being extended-spectrum β-lactamase or plasmid-mediated AmpC β-lactamase co-producers. No mcr-2 gene was detected. Our findings highlight the spread of mcr-1 genes within a wide-ranging sample of food-producing animals and meat, in Portugal.
我们在 2010 年至 2015 年期间，从食品生产动物、肉类、肉类产品和动物饲料中筛选了 1840 株肠杆菌科分离株，以检测质粒介导的多粘菌素耐药性。在 8.0%（97/1206）的大肠杆菌和 0.47%（3/634）的沙门氏菌分离株中检测到 mcr-1 基因，其中大量 mcr-1 阳性大肠杆菌分离株（45.7%）为产超广谱β-内酰胺酶或质粒介导的 AmpCβ-内酰胺酶共生产者。未检测到 mcr-2 基因。我们的研究结果强调了 mcr-1 基因在葡萄牙广泛的食品生产动物和肉类样本中的传播。
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