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Mechanism of dimethylnitrosamine metabolism and activation in rats.

作者信息

Godoy H M, Diaz Gomez M I, Castro J A

出版信息

J Natl Cancer Inst. 1978 Nov;61(5):1285-9. doi: 10.1093/jnci/61.5.1285.

DOI:10.1093/jnci/61.5.1285
PMID:30846
Abstract
摘要

相似文献

1
Mechanism of dimethylnitrosamine metabolism and activation in rats.大鼠体内二甲基亚硝胺的代谢及活化机制
J Natl Cancer Inst. 1978 Nov;61(5):1285-9. doi: 10.1093/jnci/61.5.1285.
2
Studies on the metabolism of dimethylnitrosamine in the rat. II. The effects of phenobarbitone and 20-methylcholanthrene on the in vitro and in vivo metabolism and acute toxicity of dimethylnitrosamine in young and mature rats.
Food Cosmet Toxicol. 1975 Dec;13(6):611-7. doi: 10.1016/0015-6264(75)90150-9.
3
Deuterium isotope effect in the microsomal metabolism of dimethylnitrosamine.二甲基亚硝胺微粒体代谢中的氘同位素效应。
J Natl Cancer Inst. 1976 Oct;57(4):955-7. doi: 10.1093/jnci/57.4.955.
4
The hepatic metabolism of 15N labelled dimethylnitrosamine in the rat.大鼠体内15N标记的二甲基亚硝胺的肝脏代谢
Biochem Pharmacol. 1977 Apr 15;26(8):809-13. doi: 10.1016/0006-2952(77)90234-9.
5
Investigations into the hepatic metabolism of dimethylnitrosamine in the rat.大鼠体内二甲基亚硝胺肝脏代谢的研究。
Life Sci. 1975 Nov 15;17(10):1599-606. doi: 10.1016/0024-3205(75)90182-4.
6
The distribution of [14C]dimethylnitrosamine in mice. Autoradiographic studies in mice with inhibited and noninhibited dimethylnitrosamine metabolism and a comparison with the distribution of [14C]formaldehyde.
Toxicol Appl Pharmacol. 1978 Aug;45(2):565-75. doi: 10.1016/0041-008x(78)90118-7.
7
Near quantitative production of molecular nitrogen from metabolism of dimethylnitrosamine.二甲基亚硝胺代谢产生近乎定量的分子氮。
Biochem Biophys Res Commun. 1979 Mar 15;87(1):337-42. doi: 10.1016/0006-291x(79)91684-x.
8
The binding of dimethylnitrosamine to nucleic acids catalyzed by liver enzymic fractions.肝酶组分催化二甲基亚硝胺与核酸的结合。
Cancer Lett. 1975 Nov;1(2):85-90. doi: 10.1016/s0304-3835(75)95496-8.
9
Kinetic studies on the hepatic microsomal metabolism of dimethylnitrosamine, diethylnitrosamine, and methylethylnitrosamine in the rat.大鼠肝脏微粒体对二甲基亚硝胺、二乙基亚硝胺和甲基乙基亚硝胺代谢的动力学研究。
J Natl Cancer Inst. 1978 Aug;61(2):517-21.
10
Factors affecting metabolism and mutagenicity of dimethylnitrosamine and diethylnitrosamine.影响二甲基亚硝胺和二乙基亚硝胺代谢及致突变性的因素。
Cancer Res. 1975 Sep;35(9):2307-14.

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Trans-2-nonadecyl-4-(hydroxymethyl)-1,3-dioxolane (TNHD) purified from freshwater clams markedly alleviates dimethylnitrosamine-induced hepatic fibrosis.从淡水蛤中提取的反-2-壬基-4-(羟甲基)-1,3-二恶烷（TNHD）显著缓解二甲基亚硝胺诱导的肝纤维化。
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Further studies on dimethylnitrosamine metabolism, activation and its ability to cause liver injury.关于二甲基亚硝胺代谢、活化及其致肝损伤能力的进一步研究。
Arch Toxicol. 1981 Jun;47(3):159-68. doi: 10.1007/BF00368676.
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Histochemical localization of primary and secondary alcohol dehydrogenases in whole-body, freeze-dried sections of mice.
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Nature of N-nitrosodimethylamine demethylase in hepatic microsomes of rats.大鼠肝微粒体中N-亚硝基二甲胺脱甲基酶的性质
Arch Toxicol. 1984 Nov;56(1):7-11. doi: 10.1007/BF00316344.
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The effect of mixed-function oxidase and amine oxidase inhibitors on the activation of dialkylnitrosamines and 1,2-dimethylhydrazine to bacterial mutagens in mice.混合功能氧化酶和胺氧化酶抑制剂对小鼠体内二烷基亚硝胺和1,2 - 二甲基肼激活为细菌诱变剂的影响。
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