二甲基亚硝胺微粒体代谢中的氘同位素效应。
Deuterium isotope effect in the microsomal metabolism of dimethylnitrosamine.
作者信息
Dagani D, Archer M C
出版信息
J Natl Cancer Inst. 1976 Oct;57(4):955-7. doi: 10.1093/jnci/57.4.955.
PMID:1003536
Abstract
The rates of N-demethylation of dimethylnitrosamine and dimethylnitrosamine-d6 by rat liver microsomes were studied by monitoring formaldehyde production. Deuterium isotope effects of 1.6 and 3.8 were found for the Michaelis constant and the maximum velocity, respectively.
摘要
通过监测甲醛生成情况，研究了大鼠肝微粒体对二甲基亚硝胺和二甲基亚硝胺 - d6的N - 去甲基化速率。发现米氏常数和最大反应速度的氘同位素效应分别为1.6和3.8。
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