Havell E A
J Infect Dis. 1986 May;153(5):960-9. doi: 10.1093/infdis/153.5.960.
Mice infected iv with an immunizing dose of the gram-positive bacterium, Listeria monocytogenes, produced circulating interferon (IFN) during the inductive phase of the immune response to Listeria. Listeria infection also dramatically altered the host's responsiveness to IFN-inducing agents. Within 24 hr of infection, mice acquired a 50-fold greater than normal capacity to produce the IFN alpha and/or IFN beta classes (IFN alpha/beta) following iv injection of endotoxin. Serum levels of IFN alpha/beta peaked by 2 hr, after which high levels of IFN gamma were detected in the sera of Listeria-infected mice given the B cell mitogen. Similar studies carried out with the interferon-inducing agent polyinosinic-polycytidylic acid (poly(I).poly(C) revealed that mice infected for 24 hr produced only 4-8 times more IFN alpha/beta than did noninfected mice. Unlike endotoxin, however, poly(I).poly(C) did not induce IFN gamma in Listeria-infected animals.
经静脉注射免疫剂量的革兰氏阳性细菌——单核细胞增生李斯特菌感染的小鼠，在对李斯特菌免疫反应的诱导阶段产生了循环干扰素（IFN）。李斯特菌感染还显著改变了宿主对IFN诱导剂的反应性。感染后24小时内，经静脉注射内毒素后，小鼠产生I型干扰素（IFNα和/或IFNβ，即IFNα/β）的能力比正常情况高50倍。IFNα/β的血清水平在2小时时达到峰值，此后，在给予B细胞促有丝分裂原的李斯特菌感染小鼠血清中检测到高水平的IFNγ。用干扰素诱导剂聚肌苷酸-聚胞苷酸（poly(I)·poly(C)）进行的类似研究表明，感染24小时的小鼠产生的IFNα/β仅比未感染小鼠多4 - 8倍。然而，与内毒素不同，poly(I)·poly(C)在李斯特菌感染的动物中不诱导IFNγ。
