Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan.
Department of Otolaryngology-Head & Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan.
Sci Rep. 2019 Mar 7;9(1):3877. doi: 10.1038/s41598-019-40629-z.
Because of innumerable cancer sequencing projects, abundant transcriptome expression profiles together with survival data are available from the same patients. Although some expression signatures for prognosis or pathologic staging have been identified from these data, systematically discovering such kind of expression signatures remains a challenge. To address this, we developed TACCO (Transcriptome Alterations in CanCer Omnibus), a database for identifying differentially expressed genes and altered pathways in cancer. TACCO also reveals miRNA cooperative regulations and supports construction of models for prognosis. The resulting signatures have great potential for patient stratification and treatment decision-making in future clinical applications. TACCO is freely available at http://tacco.life.nctu.edu.tw/ .
由于无数的癌症测序项目，从同一患者中获得了丰富的转录组表达谱和生存数据。尽管已经从这些数据中确定了一些用于预后或病理分期的表达特征，但系统地发现这种表达特征仍然是一个挑战。为了解决这个问题，我们开发了 TACCO（癌症综合转录组改变数据库），这是一个用于识别癌症中差异表达基因和改变途径的数据库。TACCO 还揭示了 miRNA 的协同调控，并支持预后模型的构建。由此产生的特征在未来的临床应用中具有很大的潜力，可以用于患者分层和治疗决策。TACCO 可在 http://tacco.life.nctu.edu.tw/ 免费获得。
