Kubota T, Nishi N, Saito M, Suzuki A, Yaoi Y, Kumasaka T
Nihon Sanka Fujinka Gakkai Zasshi. 1986 Apr;38(4):545-53.
The purpose of this study was to investigate the correlation between gonadotropin (Gn) and prolactin (PRL) releasing activities on the hypothalamo-pituitary axis in the luteal phase of the normal menstrual cycle and in the early gestational period. The plasma levels of LH-beta subunit (LH-beta) following an intravenous bolus of 100 micrograms LHRH did not change significantly in early pregnancy. The plasma PRL levels, as well as the Gn levels, were significantly elevated (p less than 0.05) after the administration of 100 micrograms LHRH in the luteal phase, but did not rise in early pregnancy. The intravenous bolus of 10mg metoclopramide (MCP) had no effect on plasma LH-beta, LH, FSH, estradiol or progesterone in the luteal phase or early pregnancy. The plasma PRL levels remained significantly (p less than 0.001) elevated after the administration of MCP. However, there was no significant difference between PRL response to MCP in the early pregnant and luteal phase groups. In the luteal phase, we could show the correlation between Gn and PRL releasing mechanisms on hypothalamo-pituitary axis, which could not be found in early pregnancy.
本研究的目的是调查正常月经周期黄体期和妊娠早期下丘脑 - 垂体轴上促性腺激素（Gn）与催乳素（PRL）释放活性之间的相关性。静脉注射100微克促性腺激素释放激素（LHRH）后，妊娠早期血浆促黄体生成素β亚基（LH-β）水平无显著变化。在黄体期静脉注射100微克LHRH后，血浆PRL水平以及Gn水平显著升高（p<0.05），但在妊娠早期未升高。静脉注射10毫克甲氧氯普胺（MCP）对黄体期或妊娠早期的血浆LH-β、LH、促卵泡生成素（FSH）、雌二醇或孕酮无影响。注射MCP后，血浆PRL水平仍显著升高（p<0.001）。然而，妊娠早期组和黄体期组对MCP的PRL反应无显著差异。在黄体期，我们可以显示下丘脑 - 垂体轴上Gn与PRL释放机制之间的相关性，而在妊娠早期未发现这种相关性。
