白细胞介素1和脂多糖在体内及培养的内皮细胞中均可诱导组织型纤溶酶原激活物的一种抑制剂产生。
Interleukin 1 and lipopolysaccharide induce an inhibitor of tissue-type plasminogen activator in vivo and in cultured endothelial cells.
作者信息
Emeis J J, Kooistra T
出版信息
J Exp Med. 1986 May 1;163(5):1260-6. doi: 10.1084/jem.163.5.1260.
Abstract
Human IL-1, recombinant murine IL-1 and E. coli LPS were found to be potent inducers of plasminogen activator (PA)-inhibitor activity, both in vivo, in rats, as well as in cultured human endothelial cells. In vivo, LPS rapidly and dose-dependently (0.01-1,000 micrograms/kg) increased plasma PA-inhibitor activity. Infusion of IL-1 into rats resulted in a small but significant increase in PA-inhibitor activity in rat plasma. Likewise, in cultured human umbilical vein endothelial cells, LPS and IL-1 induced increased synthesis of PA-inhibitor. We suggest that the induced rat plasma inhibitor might be of endothelial origin.
摘要
已发现，人白细胞介素-1、重组鼠白细胞介素-1和大肠杆菌脂多糖无论是在大鼠体内还是在培养的人内皮细胞中，都是纤溶酶原激活物（PA）抑制活性的有效诱导剂。在体内，脂多糖在大鼠中迅速且呈剂量依赖性（0.01 - 1000微克/千克）地增加血浆PA抑制活性。向大鼠输注白细胞介素-1导致大鼠血浆中PA抑制活性有小幅但显著的增加。同样，在培养的人脐静脉内皮细胞中，脂多糖和白细胞介素-1诱导PA抑制剂的合成增加。我们认为诱导产生的大鼠血浆抑制剂可能来源于内皮细胞。
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Interleukin 1 and lipopolysaccharide induce an inhibitor of tissue-type plasminogen activator in vivo and in cultured endothelial cells.白细胞介素1和脂多糖在体内及培养的内皮细胞中均可诱导组织型纤溶酶原激活物的一种抑制剂产生。
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