白细胞介素1可诱导内皮细胞合成纤溶酶原激活物抑制剂。
Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor.
作者信息
Nachman R L, Hajjar K A, Silverstein R L, Dinarello C A
出版信息
J Exp Med. 1986 Jun 1;163(6):1595-600. doi: 10.1084/jem.163.6.1595.
Abstract
Human endothelial cells activated with IL-1 express a surface membrane-oriented procoagulant generating system characterized by increased tissue factor synthesis and decreased thrombomodulin activity. We now report that IL-1 also stimulates endothelial cell synthesis of plasminogen activator inhibitor. This array of IL-1-induced activities shifts the balance at the endothelial cell surface to a prothrombotic influence and may reflect an early response of the blood vessel wall to injury.
摘要
用白细胞介素-1激活的人内皮细胞表达一种以组织因子合成增加和血栓调节蛋白活性降低为特征的面向表面膜的促凝血生成系统。我们现在报告白细胞介素-1还刺激内皮细胞合成纤溶酶原激活物抑制剂。白细胞介素-1诱导的这一系列活性将内皮细胞表面的平衡转向促血栓形成影响，这可能反映了血管壁对损伤的早期反应。
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