Ortiz-Arrambide Miguel Angel, Juarez-Ibarra Karla Isabel, Malagón-Santiago Guadalupe Ismael, Cruz-Fierro Norma, De La Garza-Ramos Myriam Angelica
Facultad de Odontologia Universidad Autonoma de Nuevo Leon Monterrey Mexico.
Centro de Investigación y Desarrollo en Ciencias de la Salud (CIDICS) Universidad Autonoma de Nuevo Leon Monterrey Mexico.
Clin Exp Dent Res. 2018 Dec 5;5(1):14-18. doi: 10.1002/cre2.150. eCollection 2019 Feb.
Diabetes mellitus (DM) is a frequent worldwide disease. There are currently more than 46 million people who suffer this disease in North America and the Caribbean. The objective of this study was to determine if there is an association between DM and the presence of iron precipitates (Fe) in dental structure. The third molar was extracted for reasons that merit extraction from 40 individuals with and without DM to analyze dentin tissue. Horizontal and longitudinal slices of tooth samples were made and later stained with 10% potassium cyanoferrate. The samples were observed by optical microscope to identify basophilic elements. A nonparametric Spearman correlation was performed to find an association between the quantitative (gender, group, and dentinal tissue) and qualitative variables (gender). The Mann-Whitney U test was used to find differences in the means of the nonparametric variables in two different groups in relation to the value (<0.05). Iron elements were found in the predentin and circumpulpal dentin areas, and the results obtained showed a statistically significant difference between dentin tissue from patients with diabetes and those without. Individuals with Type 2 DM are prone to present iron precipitates in predentin and circumpulpal dentin tissue. Few iron elements were found in dental organs of individuals without DM.
糖尿病（DM）是一种在全球范围内常见的疾病。目前在北美和加勒比地区有超过4600万人患有这种疾病。本研究的目的是确定糖尿病与牙齿结构中是否存在铁沉淀物（Fe）之间是否存在关联。从40名患有和未患有糖尿病的个体中，出于值得拔牙的原因拔除第三磨牙，以分析牙本质组织。制作牙齿样本的水平和纵向切片，随后用10%铁氰化钾染色。通过光学显微镜观察样本以识别嗜碱性元素。进行非参数Spearman相关性分析以找出定量（性别、组别和牙本质组织）和定性变量（性别）之间的关联。使用Mann-Whitney U检验来找出两个不同组中非参数变量均值相对于 值（<0.05）的差异。在前牙本质和牙髓周牙本质区域发现了铁元素，所得结果显示糖尿病患者和非糖尿病患者的牙本质组织之间存在统计学上的显著差异。2型糖尿病个体在前牙本质和牙髓周牙本质组织中容易出现铁沉淀物。在非糖尿病个体的牙齿器官中发现的铁元素很少。
