Vahedi Parisa, Bagheri Nikta, Khoramian Tusi Somayeh, Mohammadian Manijeh
Department of Pediatric Dentistry, Alborz University of Medical Sciences, Karaj, Iran.
Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran.
BMC Oral Health. 2025 Sep 24;25(1):1428. doi: 10.1186/s12903-025-06846-x.
Iron supplements can cause discoloration in children's teeth, which can impact their confidence and social interactions. This staining may discourage parents from continuing treatment. The study compared different types of iron supplements-encapsulated (liposomal, sucrosomial) and non-encapsulated (ferrous sulfate, iron polysaccharide complex)-to assess their impact on tooth discoloration.
In this in vitro study, a total of 65 intact anterior primary teeth were examined. Their initial color was assessed using an X-RITE spectrophotometer in the CIELab system. The control group was treated with normal saline, while experimental groups were exposed to iron supplements: Liposofer, Amivital Ferrous Sulphate, SiderAl, and Feramax. The teeth were immersed in these solutions for two weeks before final color measurements. SPSS software version 27 was used for statistical analysis, including paired t-tests, one-way ANOVA, LSD multiple comparison tests, Tamhane's T2 test, and the Shapiro-Wilk test. The level of statistical significance was set at P < 0.05.
The mean ∆E parameter (color assessment) of primary teeth was significantly higher in the groups treated with Amivital Ferrous Sulphate and SiderAl iron supplements compared to the other groups (P < 0.05). Among the iron supplements, Liposofer and Feramax showed the lowest mean ∆E parameter for primary teeth (P < 0.05).
The type of iron supplement may play a key role in primary tooth discoloration. These findings suggest that polysaccharide and liposomal iron supplements may cause less discoloration in vitro, though further clinical research is needed to confirm these findings.
铁补充剂会导致儿童牙齿变色，这可能会影响他们的自信心和社交互动。这种染色可能会使家长不愿继续治疗。该研究比较了不同类型的铁补充剂——胶囊型（脂质体、蔗糖体）和非胶囊型（硫酸亚铁、铁多糖复合物）——以评估它们对牙齿变色的影响。
在这项体外研究中，共检查了65颗完整的上前乳牙。使用X-RITE分光光度计在CIELab系统中评估其初始颜色。对照组用生理盐水处理，而实验组则接触铁补充剂：Liposofer、Amivital硫酸亚铁、SiderAl和Faramax。在进行最终颜色测量前，将牙齿浸泡在这些溶液中两周。使用SPSS 27版软件进行统计分析，包括配对t检验、单因素方差分析、LSD多重比较检验、Tamhane's T2检验和Shapiro-Wilk检验。统计学显著性水平设定为P < 0.05。
与其他组相比，用Amivital硫酸亚铁和SiderAl铁补充剂处理的组中乳牙的平均∆E参数（颜色评估）显著更高（P < 0.05）。在铁补充剂中，Liposofer和Faramax对乳牙显示出最低的平均∆E参数（P < 0.05）。
铁补充剂的类型可能在乳牙变色中起关键作用。这些发现表明，多糖和脂质体铁补充剂在体外可能导致较少的变色，不过需要进一步的临床研究来证实这些发现。
