Hanold K C
J Obstet Gynecol Neonatal Nurs. 1986 Mar-Apr;15(2):111-6. doi: 10.1111/j.1552-6909.1986.tb01376.x.
Valproic acid administration in pregnancy may be a potential teratogen to the developing fetus. Numerous animal studies have linked valproic acid to vertebral anomalies and renal agenesis. Recent European data have suggested valproic acid as a causal agent of neural tube defects in human offspring. Research relative to teratogenicity of valproic acid administration for petit mal epilepsy is reviewed. Conclusions indicate that the benefits of valproic acid administration outweigh the hazards of teratogenicity.
孕期使用丙戊酸可能对发育中的胎儿具有潜在致畸性。大量动物研究已将丙戊酸与脊柱异常和肾发育不全联系起来。欧洲近期的数据表明丙戊酸是人类后代神经管缺陷的致病因素。本文综述了关于丙戊酸用于治疗小儿癫痫的致畸性研究。结论表明，使用丙戊酸的益处超过了致畸风险。
