Department of Neurology The Third Affiliated Hospital of Sun Yat-Sen University Guangzhou 510630 China.
Department of Neurology the Second Affiliated Hospital of Guangzhou Medical University Guangzhou 510260 China.
Ann Clin Transl Neurol. 2019 Jan 8;6(2):392-396. doi: 10.1002/acn3.712. eCollection 2019 Feb.
Our objective was to examine the brain biopsies by histopathology and investigate the prognosis of patients with myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor. The clinical, MRI, and histological features of two patients with myelin oligodendrocyte glycoprotein antibody-associated demyelinating pseudotumor were reviewed. Both patients were treated with steroid plus rituximab and followed up. The brain biopsies of both cases revealed T cells, macrophages, and complement-mediated demyelination, which was in accord with multiple sclerosis-like pathology. Moreover, both cases showed favorable response to steroid plus rituximab therapy. Our cases add a new variant to the myelin oligodendrocyte glycoprotein-encephalomyelitis spectrum, which favorably responds to immunotherapy.
我们的目的是通过组织病理学检查脑活检，并研究髓鞘少突胶质细胞糖蛋白抗体相关脱髓鞘假瘤患者的预后。我们回顾了两名髓鞘少突胶质细胞糖蛋白抗体相关脱髓鞘假瘤患者的临床、MRI 和组织学特征。两名患者均接受类固醇加利妥昔单抗治疗并随访。这两个病例的脑活检均显示 T 细胞、巨噬细胞和补体介导的脱髓鞘，这与多发性硬化样病理学相符。此外，这两个病例对类固醇加利妥昔单抗治疗均有良好反应。我们的病例为髓鞘少突胶质细胞糖蛋白脑炎谱增加了一种新的变体，该变体对免疫疗法有良好的反应。
