Clinic of Physical Medicine and Rehabilitation, University Clinical Centre of Kosovo, Pristina, Kosovo.
Rheumatology Clinic, University Clinical Centre of Kosovo, Pristina, Kosovo.
Rheumatol Int. 2019 May;39(5):827-834. doi: 10.1007/s00296-019-04258-z. Epub 2019 Mar 7.
Routine assessment of patient index data 3 (RAPID3) is a simple, valid and reliable tool designed to measure disease activity in patients with rheumatoid arthritis (RA). RA causes significant disability and diminishes health-related quality of life (HR-QoL). The aim of this study was to investigate how RAPID3 is related to HR-QoL in patients with RA. In this cross-sectional study performed at the tertiary outpatient clinic 68 consecutive patients (58 females, and 10 males) with established RA were enrolled. RAPID3 and EuroQoL-5D-3L (EQ-5D-3L) were used to measure disease activity and quality of life, respectively. Alongside, demographic and clinical data were obtained, as well as HAQ-DI as a measure of physical function, and Steinbrocker's score for radiographic damage. To test the relationships among RAPID3 and study variables we used the Pearson product-moment correlation coefficient, with the significance was set at P < 0.05. Linear and forward stepwise regression was used to show how variables of interest contributed to RAPID3. The mean value of RAPID3 (standard deviation, SD) was 14.12 (± 5.21), while the median (IQR) value of EQ-5D-3L was 0.51 (0.62-0.23). There was a high significant correlation (r = - 0.73) between RAPID3 scores and EQ-5D-3L. Among the other variables of interest, the strongest correlation was found between RAPID3 and intensity of pain (r = 0.88), while the EQ-5D-3L and pain were moderately correlated (r = - 0.68). In evaluating the influence of variables of interest on RAPID3, a forward stepwise regression model was constructed to evaluate whether VAS pain, EQ-5D-3L and EQ-VAS predicted RAPID3. The given variables significantly explained approximately 81% of the variation in RAPID3. Based on the results of this study RAPID3, a simple and practical tool to assess disease activity, reflects well HR-QoL in patients with established RA.
常规评估患者指数数据 3（RAPID3）是一种简单、有效且可靠的工具，旨在衡量类风湿关节炎（RA）患者的疾病活动度。RA 会导致显著的残疾和降低健康相关生活质量（HR-QoL）。本研究的目的是探讨 RAPID3 与 RA 患者 HR-QoL 的关系。在这项在三级门诊诊所进行的横断面研究中，纳入了 68 例确诊的 RA 患者（58 名女性，10 名男性）。分别使用 RAPID3 和 EuroQoL-5D-3L（EQ-5D-3L）来衡量疾病活动度和生活质量。此外，还获得了人口统计学和临床数据，以及 HAQ-DI 作为身体功能的衡量标准和 Steinbrocker 放射学损伤评分。为了检验 RAPID3 与研究变量之间的关系，我们使用了 Pearson 积差相关系数，显著性水平设为 P < 0.05。使用线性和逐步向前回归来显示感兴趣的变量如何对 RAPID3 做出贡献。RAPID3 的平均值（标准差，SD）为 14.12（±5.21），而 EQ-5D-3L 的中位数（IQR）为 0.51（0.62-0.23）。RAPID3 评分与 EQ-5D-3L 之间存在高度显著的相关性（r = -0.73）。在其他感兴趣的变量中，RAPID3 与疼痛强度之间的相关性最强（r = 0.88），而 EQ-5D-3L 与疼痛之间的相关性则适中（r = -0.68）。在评估感兴趣变量对 RAPID3 的影响时，构建了一个逐步向前回归模型，以评估 VAS 疼痛、EQ-5D-3L 和 EQ-VAS 是否可以预测 RAPID3。这些变量可以显著解释 RAPID3 约 81%的变异。基于这项研究的结果，RAPID3 是一种简单实用的评估疾病活动度的工具，能很好地反映出确诊 RA 患者的 HR-QoL。
