Department of Developmental Disability Neuropsychiatry (3DN), UNSW Sydney, 34 Botany St, Sydney, NSW, 2052, Australia.
Cooperative Research Centre for Living with Autism (Autism CRC), Brisbane, QLD, Australia.
J Autism Dev Disord. 2020 Jun;50(6):2217-2225. doi: 10.1007/s10803-019-03947-9.
Despite the high prevalence of depression and other mental illnesses in autistic adults, screening instruments such as the Patient Health Questionnaire (PHQ-9) have not been specifically validated in an autistic sample. Using data from two Autism CRC longitudinal studies (n = 581), confirmatory factor analysis supported the two-factor model (somatic and cognitive/affective) in the autistic sample and one-factor model in the community comparison sample. Confirmatory bifactor analysis also supported use of the PHQ-9 total score in autism. Good convergent validity was found with two measures of psychological well-being for PHQ-9 total and subdomain scores. The PHQ-9 is a useful tool for autism research allowing comparison across autistic and non-autistic participants.
尽管自闭症成年人中抑郁和其他精神疾病的患病率很高，但像 PHQ-9 这样的筛查工具尚未在自闭症患者中得到专门验证。使用来自两个 Autism CRC 纵向研究的数据（n=581），验证性因子分析支持自闭症样本中的两因素模型（躯体和认知/情感）和社区比较样本中的单因素模型。验证性双因素分析也支持在自闭症中使用 PHQ-9 总分。PHQ-9 总分和子量表得分与两种心理健康测量方法具有良好的收敛效度。PHQ-9 是自闭症研究的有用工具，允许自闭症和非自闭症参与者进行比较。
