Department of Radiological Technology, Kurashiki Central Hospital, Kurashiki, Japan.
Department of Quantum Medical Technology, Kanazawa University, Kanazawa, Japan.
J Nucl Cardiol. 2021 Feb;28(1):236-244. doi: 10.1007/s12350-019-01677-0. Epub 2019 Mar 7.
The spectrum dynamics (SD) algorithm is a cardiac reconstruction algorithm of D-SPECT, which improves spatial resolution compared with the ordered-subsets expectation maximization (OSEM) algorithm. We evaluated the wall thickness and left ventricular (LV) volume in patients with hypertrophic cardiomyopathy (HCM) using the SD algorithm.
In a phantom study, the myocardial wall was scanned with varying wall thicknesses (10-40 mm). In the clinical study, 30 and 27 normal and HCM patients underwent myocardial perfusion imaging.
In a phantom study, LV volume using the SD algorithm was increased by thickening the wall of the phantom. In the clinical study, the wall thickness and LV volume of OSEM and SD algorithms showed a difference between HCM and normal groups. The wall thickness using OSEM and SD algorithms were 19.4 ± 2.0 and 16.7 ± 1.5 mm in patients with normal, and 27.9 ± 4.9 and 21.8 ± 2.6 mm in patients with HCM.
The SD algorithm in cases of HCM may not be able to correctly assess wall thickness and LV volume. Our study suggests that the OSEM is more suitable in cases of HCM than the SD algorithm.
SD 算法是 D-SPECT 的心脏重建算法，与有序子集期望最大化（OSEM）算法相比，它提高了空间分辨率。我们使用 SD 算法评估肥厚型心肌病（HCM）患者的壁厚度和左心室（LV）容积。
在体模研究中，用不同的壁厚度（10-40mm）扫描心肌壁。在临床研究中，30 名和 27 名正常和 HCM 患者进行了心肌灌注成像。
在体模研究中，SD 算法的 LV 容积随壁的增厚而增加。在临床研究中，OSEM 和 SD 算法的壁厚度和 LV 容积在 HCM 和正常组之间存在差异。OSEM 和 SD 算法在正常患者中的壁厚度分别为 19.4±2.0 和 16.7±1.5mm，在 HCM 患者中分别为 27.9±4.9 和 21.8±2.6mm。
在 HCM 病例中，SD 算法可能无法正确评估壁厚度和 LV 容积。我们的研究表明，与 SD 算法相比，OSEM 更适合 HCM 病例。
